Interleukin 13 receptor, alpha 1 explained

Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1), is a human gene.^[1]

The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.^[2]

IL13RA1 expression has been linked to higher survival rates for lung cancer patients.^[3]

See also

• Interleukin-13 receptor

Further reading

• Kornau HC, Schenker LT, Kennedy MB, Seeburg PH . Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95 . Science . 269 . 5231 . 1737–40 . 1995 . 7569905 . 10.1126/science.7569905 . 1995Sci...269.1737K .
• Aman MJ, Tayebi N, Obiri NI, etal . cDNA cloning and characterization of the human interleukin 13 receptor alpha chain . J. Biol. Chem. . 271 . 46 . 29265–70 . 1997 . 8910586 . 10.1074/jbc.271.46.29265 . free .
• Miloux B, Laurent P, Bonnin O, etal . Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex . FEBS Lett. . 401 . 2–3 . 163–6 . 1997 . 9013879 . 10.1016/S0014-5793(96)01462-7 . 85249806 .
• Zhang JG, Hilton DJ, Willson TA, etal . Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains . J. Biol. Chem. . 272 . 14 . 9474–80 . 1997 . 9083087 . 10.1074/jbc.272.14.9474 . free .
• Orchansky PL, Kwan R, Lee F, Schrader JW . Characterization of the cytoplasmic domain of interleukin-13 receptor-alpha . J. Biol. Chem. . 274 . 30 . 20818–25 . 1999 . 10409622 . 10.1074/jbc.274.30.20818 . free .
• Osawa M, Miyoshi S, Copeland NG, etal . Characterization of the mouse interleukin-13 receptor alpha1 gene . Immunogenetics . 51 . 11 . 974–81 . 2000 . 11003391 . 10.1007/s002510000225 . 9030454 .
• Umeshita-Suyama R, Sugimoto R, Akaiwa M, etal . Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation . Int. Immunol. . 12 . 11 . 1499–509 . 2000 . 11058569 . 10.1093/intimm/12.11.1499 . free .
• Oshima Y, Puri RK . Characterization of a powerful high affinity antagonist that inhibits biological activities of human interleukin-13 . J. Biol. Chem. . 276 . 18 . 15185–91 . 2001 . 11278629 . 10.1074/jbc.M010159200 . free .
• Kawakami M, Leland P, Kawakami K, Puri RK . Mutation and functional analysis of IL-13 receptors in human malignant glioma cells . Oncol. Res. . 12 . 11–12 . 459–67 . 2002 . 11939409 . 10.3727/096504001108747468. free .
• Roy B, Bhattacharjee A, Xu B, etal . IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats . J. Leukoc. Biol. . 72 . 3 . 580–9 . 2002 . 10.1189/jlb.72.3.580 . 12223527 . 9279523 . free .
• Andrews AL, Holloway JW, Puddicombe SM, etal . Kinetic analysis of the interleukin-13 receptor complex . J. Biol. Chem. . 277 . 48 . 46073–8 . 2003 . 12354755 . 10.1074/jbc.M209560200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Nagarkatti R, Ghosh B . Identification of single-nucleotide and repeat polymorphisms in two candidate genes, interleukin 4 receptor (IL4RA) and signal transducer and activator of transcription protein 6 (STAT6), for Th2-mediated diseases . J. Hum. Genet. . 47 . 12 . 684–7 . 2003 . 12522691 . 10.1007/s100380200105 . free .
• He JQ, Connett JE, Anthonisen NR, Sandford AJ . Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate of decline in lung function in smokers . Am. J. Respir. Cell Mol. Biol. . 28 . 3 . 379–85 . 2003 . 12594065 . 10.1165/rcmb.4885 .
• Niu Y, Murata T, Watanabe K, etal . MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation . FEBS Lett. . 550 . 1–3 . 139–43 . 2003 . 12935900 . 10.1016/S0014-5793(03)00860-3 . 2517010 . free .
• Wongpiyabovorn J, Suto H, Ushio H, etal . Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis . J. Dermatol. Sci. . 33 . 1 . 31–40 . 2004 . 14527737 . 10.1016/S0923-1811(03)00148-8 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 .
• Arima K, Sato K, Tanaka G, etal . Characterization of the interaction between interleukin-13 and interleukin-13 receptors . J. Biol. Chem. . 280 . 26 . 24915–22 . 2005 . 15870068 . 10.1074/jbc.M502571200 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kaur D, Hollins F, Woodman L, etal . Mast cells express IL-13R alpha 1: IL-13 promotes human lung mast cell proliferation and Fc epsilon RI expression . Allergy . 61 . 9 . 1047–53 . 2007 . 16918506 . 10.1111/j.1398-9995.2006.01139.x . 11962277 .

Notes and References

1. Web site: Entrez Gene: IL13RA1 interleukin 13 receptor, alpha 1.
2. Web site: Entrez Gene: IL13RA1 interleukin 13 receptor, alpha 1.
3. Web site: Research update from the MCM team (November 2023). World Community Grid. 27 November 2023. 21 May 2024.