IKZF4 explained

Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.^{[1] [2]}

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM]^[2]

Interactions

IKZF4 has been shown to interact with CTBP1^[3] and IKZF1.^[4]

Further reading

• Kimura K . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 . vanc. Wakamatsu A . Suzuki Y . 3 . Ota . T . Nishikawa . T . Yamashita . R . Yamamoto . J . Sekine . M . Tsuritani . K .
• Bao J . Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos . Nat. Neurosci. . 7 . 11 . 1250–8 . 2005 . 15494726 . 10.1038/nn1342 . vanc. Lin H . Ouyang Y . 3 . Lei . Debin . Osman . Abdullah . Kim . Tae-Wan . Mei . Lin . Dai . Penggao . Ohlemiller . Kevin K . 1964177 .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Perdomo J, Crossley M . The Ikaros family protein Eos associates with C-terminal-binding protein corepressors . Eur. J. Biochem. . 269 . 23 . 5885–92 . 2003 . 12444977 . 10.1046/j.1432-1033.2002.03313.x . free .
• Koipally J, Georgopoulos K . A molecular dissection of the repression circuitry of Ikaros . J. Biol. Chem. . 277 . 31 . 27697–705 . 2002 . 12015313 . 10.1074/jbc.M201694200 . free .
• Nagase T . Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 8 . 2 . 85–95 . 2001 . 11347906 . 10.1093/dnares/8.2.85 . vanc. Nakayama M . Nakajima D . 3 . Kikuno . R . Ohara . O . free.
• Honma Y . Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system . FEBS Lett. . 447 . 1 . 76–80 . 1999 . 10218586 . 10.1016/S0014-5793(99)00265-3 . vanc. Kiyosawa H . Mori T . 3 . Oguri . A . Nikaido . T . Kanazawa . K . Tojo . M . Takeda . J . Tanno . Y . 28898354 . free .

Notes and References

1. Perdomo J, Holmes M, Chong B, Crossley M . Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities . J Biol Chem . 275 . 49 . 38347–54 . Jan 2001 . 10978333 . 10.1074/jbc.M005457200 . free .
2. Web site: Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos).
3. Perdomo . José . Crossley Merlin . Dec 2002 . The Ikaros family protein Eos associates with C-terminal-binding protein corepressors . Eur. J. Biochem. . 269 . 23 . 5885–92 . Germany. 0014-2956. 12444977 . 10.1046/j.1432-1033.2002.03313.x . free .
4. Honma . Y . Kiyosawa H . Mori T . Oguri A . Nikaido T . Kanazawa K . Tojo M . Takeda J . Tanno Y . Yokoya S . Kawabata I . Ikeda H . Wanaka A . Mar 1999 . Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system . FEBS Lett. . 447 . 1 . 76–80 . NETHERLANDS. 0014-5793. 10218586 . 10.1016/S0014-5793(99)00265-3 . 28898354 . free .