IHPK2 explained

Inositol hexakisphosphate kinase 2 is an enzyme that in humans is encoded by the IP6K2 gene.^{[1] [2]}

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.^[3]

Further reading

• Andersson B, Wentland MA, Ricafrente JY, etal . A "double adaptor" method for improved shotgun library construction. . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, etal . Large-scale concatenation cDNA sequencing. . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 .
• White KE, Econs MJ . Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3. . Somat. Cell Mol. Genet. . 24 . 1 . 71–4 . 1998 . 9776982 . 10.1007/BF02677496 . 22338269 .
• Saiardi A, Caffrey JJ, Snyder SH, Shears SB . The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis. . J. Biol. Chem. . 275 . 32 . 24686–92 . 2000 . 10827188 . 10.1074/jbc.M002750200 . free .
• Morrison BH, Bauer JA, Kalvakolanu DV, Lindner DJ . Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells. . J. Biol. Chem. . 276 . 27 . 24965–70 . 2001 . 11337497 . 10.1074/jbc.M101161200 . 2025680 . free .
• Saiardi A, Nagata E, Luo HR, etal . Identification and characterization of a novel inositol hexakisphosphate kinase. . J. Biol. Chem. . 276 . 42 . 39179–85 . 2001 . 11502751 . 10.1074/jbc.M106842200 . free .
• Morrison BH, Bauer JA, Hu J, etal . Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. . Oncogene . 21 . 12 . 1882–9 . 2002 . 11896621 . 10.1038/sj.onc.1205265 . 2043497 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Nagata E, Luo HR, Saiardi A, etal . Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. . J. Biol. Chem. . 280 . 2 . 1634–40 . 2005 . 15533939 . 10.1074/jbc.M409416200 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Morrison BH, Bauer JA, Lupica JA, etal . Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation. . J. Biol. Chem. . 282 . 21 . 15349–56 . 2007 . 17379600 . 10.1074/jbc.M700156200 . 2048714 . free .

See also

• Inositol-hexakisphosphate kinase

Notes and References

1. Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH . Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases . Curr Biol . 9 . 22 . 1323–6 . May 2000 . 10574768 . 10.1016/S0960-9822(00)80055-X . 15311443 . free .
2. Web site: Entrez Gene: IHPK2 inositol hexaphosphate kinase 2.
3. Web site: Entrez Gene: IHPK2 inositol hexaphosphate kinase 2.