IHPK1 explained

Inositol hexakisphosphate kinase 1 is an enzyme that in humans is encoded by the IP6K1 gene.^[1]

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing occurs for this gene; however, the full-length nature of all transcript variants has not yet been described.^[2]

Further reading

• Nagase T, Seki N, Ishikawa K, etal . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. . DNA Res. . 3 . 5 . 321–9, 341–54 . 1997 . 9039502 . 10.1093/dnares/3.5.321 . free .
• White KE, Econs MJ . Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3. . Somat. Cell Mol. Genet. . 24 . 1 . 71–4 . 1998 . 9776982 . 10.1007/BF02677496 . 22338269 .
• Schell MJ, Letcher AJ, Brearley CA, etal . PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase. . FEBS Lett. . 461 . 3 . 169–72 . 1999 . 10567691 . 10.1016/S0014-5793(99)01462-3 . 6834292 .
• Saiardi A, Erdjument-Bromage H, Snowman AM, etal . Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. . Curr. Biol. . 9 . 22 . 1323–6 . 2000 . 10574768 . 10.1016/S0960-9822(00)80055-X . 15311443 . free .
• Saiardi A, Caffrey JJ, Snyder SH, Shears SB . The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis. . J. Biol. Chem. . 275 . 32 . 24686–92 . 2000 . 10827188 . 10.1074/jbc.M002750200 . free .
• Saiardi A, Nagata E, Luo HR, etal . Identification and characterization of a novel inositol hexakisphosphate kinase. . J. Biol. Chem. . 276 . 42 . 39179–85 . 2001 . 11502751 . 10.1074/jbc.M106842200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Kamimura J, Wakui K, Kadowaki H, etal . The IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus. . J. Hum. Genet. . 49 . 7 . 360–5 . 2004 . 15221640 . 10.1007/s10038-004-0158-z . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

See also

• Inositol-hexakisphosphate kinase

Notes and References

1. Web site: Entrez Gene: IHPK1 inositol hexaphosphate kinase 1.
2. Web site: Entrez Gene: IHPK1 inositol hexaphosphate kinase 1.