IHCH-7113 explained

Drug Name:	IHCH-7113
Width:	120px
C:	14
H:	19
N:	3
Iupac Name:	(6bR,10aS)-3-methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline
Cas Number:	313368-85-3
Pubchem:	21302499
Smiles:	CN1CCN2[C@H]3CCNC[C@H]3C4=C2C1=CC=C4
Stdinchi:	1S/C14H19N3/c1-16-7-8-17-12-5-6-15-9-11(12)10-3-2-4-13(16)14(10)17/h2-4,11-12,15H,5-9H2,1H3/t11-,12-/m0/s1
Stdinchikey:	QLGUCSLWLPCOTR-RYUDHWBXSA-N

IHCH-7113 is a drug which acts as an agonist at the 5-HT_2A serotonin receptor. It was derived by structural simplification of the 5-HT_2A antagonist atypical antipsychotic drug lumateperone along with several related compounds such as IHCH-7079 and IHCH-7086, which were found to be nonhallucinogenic biased 5-HT_2A agonists that were active in antidepressant assays but did not produce psychedelic-like responding in mice. IHCH-7113 however produced a head-twitch response comparable to that of DOI or LSD, which was blocked by the 5-HT_2A antagonist MDL100907.^{[1] [2] [3]}

See also

• AAZ-A-154
• Efavirenz
• IHCH-7079
• IHCH-7086
• Lisuride
• Mefloquine
• NDTDI
• RH-34
• SCHEMBL5334361
• WAY-163909
• Z3517967757

Notes and References

1. https://patents.google.com/patent/US6552017 Robichaud AJ, et al. Substituted heterocycle fused gamma-carbolines. Patent US 6552017
2. https://patents.google.com/patent/US9315504B2 Tomesch JC, et al. Preparation of 4-((6BR,10AS)-3-methyl-2,3,6B,9,10, 10A-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo [1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone or a pharmaceutically acceptable salt thereof. Patent US 9315504
3. Cao D, Yu J, Wang H, Luo Z, Liu X, He L, Qi J, Fan L, Tang L, Chen Z, Li J, Cheng J, Wang S . 6 . Structure-based discovery of nonhallucinogenic psychedelic analogs . Science . 375 . 6579 . 403–411 . January 2022 . 35084960 . 10.1126/science.abl8615 . 246360313 .