IHCH-7086 explained

Drug Name:	IHCH-7086
Width:	120px
C:	24
H:	31
N:	3
O:	1
Iupac Name:	(6bR,10aS)-2,3,6b,7,8,9,10,10a-octahydro-8-[3-(2-methoxyphenyl)propyl]-3-methyl-1H-Pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxaline
Cas Number:	2957888-70-7
Pubchem:	162421364
Smiles:	CN(CCN1[C@]2([H])[C@@]3([H])CN(CCCC4=CC=CC=C4OC)CC2)C5=C1C3=CC=C5
Stdinchi:	InChI=1S/C24H31N3O/c1-25-15-16-27-21-12-14-26(13-6-8-18-7-3-4-11-23(18)28-2)17-20(21)19-9-5-10-22(25)24(19)27/h3-5,7,9-11,20-21H,6,8,12-17H2,1-2H3/t20-,21-/m0/s1
Stdinchikey:	WFYFRJAKNJVZMP-SFTDATJTSA-N

IHCH-7086 is a drug which acts as an agonist at the 5-HT_2A serotonin receptor. It was derived by structural simplification of the 5-HT_2A antagonist atypical antipsychotic drug lumateperone along with several related compounds such as IHCH-7079, which was found to be a non-hallucinogenic biased 5-HT_2A agonist that was active in antidepressant assays but did not produce psychedelic-like responding in mice.^{[1] [2] [3]} The related structure IHCH-7113 was found to produce a positive head-twitch response in mice, suggesting likely hallucinogenic activity in humans.

See also

• AAZ-A-154
• Efavirenz
• IHCH-7079
• IHCH-7113
• Lisuride
• Mefloquine
• NDTDI
• RH-34
• SCHEMBL5334361
• WAY-163909
• Z3517967757

Notes and References

1. Substituted heterocycle fused gamma-carbolines. . US . 6552017 . Robichaud AJ, Lee T, Deng W, Mitchell IS, Yang MG, Haydar S, Chen W, Mc Clung CD, Calvello EJ, Zawrotny DM . Bristol Myers Squibb Pharma Co. . 22 April 2003 .
2. Preparation of 4-((6BR,10AS)-3-methyl-2,3,6B,9,10, 10A-hexahydro-1H-pyrido[3′,4′:4,5]pyrrolo [1,2,3-de]quinoxalin-8-(7H)-yl)-1-(4-fluorophenyl)-1-butanone or a pharmaceutically acceptable salt thereof ]. US . 9315504 . Tomesch JC, Li P, Yao W, Zhang Q, Beard JD, Thompson AS, Cheng H, Wennogle LP . Intra Cellular Therapies Inc. . 19 April 2016 .
3. Cao D, Yu J, Wang H, Luo Z, Liu X, He L, Qi J, Fan L, Tang L, Chen Z, Li J, Cheng J, Wang S . Structure-based discovery of nonhallucinogenic psychedelic analogs . Science . 375 . 6579 . 403–411 . January 2022 . 35084960 . 10.1126/science.abl8615 . 2022Sci...375..403C . 246360313 .