IGKC explained

Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes the constant domain of kappa-type light chains for antibodies.^[1] It is found on chromosome 2, in humans, within the Immunoglobulin kappa locus, IGK@.

Further reading

• Brady RL . Crystal structure of a chimeric Fab' fragment of an antibody binding tumour cells . J. Mol. Biol. . 227 . 1 . 253–64 . 1992 . 1522589 . 10.1016/0022-2836(92)90695-G . vanc. Edwards DJ . Hubbard RE . 3 . Jiang . JS . Lange . G . Roberts . SM . Todd . RJ . Adair . JR . Emtage . JS .
• Titani K, Shinoda T, Putnam FW . The amino acid sequence of a kappa type Bence-Jones protein. 3. The complete sequence and the location of the disulfide bridges . J. Biol. Chem. . 244 . 13 . 3550–60 . 1969 . 10.1016/S0021-9258(18)83405-6 . 4893682 . free .
• Gall WE, Edelman GM . The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds . Biochemistry . 9 . 16 . 3188–96 . 1971 . 4923144 . 10.1021/bi00818a011 .
• Suter L, Barnikol HU, Watanabe S, Hilschmann N . [Rule of antibody structure. The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The complete amino acid sequence and its significance for the mechanism of antibody production] . Hoppe-Seyler's Z. Physiol. Chem. . 353 . 2 . 189–208 . 1972 . 5027703 .
• Kohler H, Shimizu A, Paul C, Putnam FW . Macroglobulin structure: variable sequence of light and heavy chains . Science . 169 . 3940 . 56–9 . 1970 . 5447531 . 10.1126/science.169.3940.56 . 1970Sci...169...56K . 28925175 .
• Gottlieb PD, Cunningham BA, Rutishauser U, Edelman GM . The covalent structure of a human gamma G-immunoglobulin. VI. Amino acid sequence of the light chain . Biochemistry . 9 . 16 . 3155–61 . 1971 . 5489770 . 10.1021/bi00818a007 .
• Hilschmann N . [The complete amino acid sequence of Bence Jones protein Cum (kappa-type)] . Hoppe-Seyler's Z. Physiol. Chem. . 348 . 12 . 1718–22 . 1968 . 5586923 .
• Klobeck HG, Combriato G, Zachau HG . Immunoglobulin genes of the kappa light chain type from two human lymphoid cell lines are closely related . Nucleic Acids Res. . 12 . 18 . 6995–7006 . 1984 . 6091049 . 10.1093/nar/12.18.6995 . 320138 .
• Hieter PA, Maizel JV, Leder P . Evolution of human immunoglobulin kappa J region genes . J. Biol. Chem. . 257 . 3 . 1516–22 . 1982 . 10.1016/S0021-9258(19)68223-2 . 6276389 . free .
• Emorine L . A conserved sequence in the immunoglobulin J kappa-C kappa intron: possible enhancer element . Nature . 304 . 5925 . 447–9 . 1983 . 6308460 . 10.1038/304447a0 . vanc. Kuehl M . Weir L . 3 . Leder . Philip . Max . Edward E. . 1983Natur.304..447E . 4304624 .
• Bentley DL, Rabbitts TH . Evolution of immunoglobulin V genes: evidence indicating that recently duplicated human V kappa sequences have diverged by gene conversion . Cell . 32 . 1 . 181–9 . 1983 . 6402305 . 10.1016/0092-8674(83)90508-1 . 21573834 .
• Hieter PA . Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments . Cell . 22 . 1 Pt 1 . 197–207 . 1981 . 6775818 . 10.1016/0092-8674(80)90168-3 . vanc. Max EE . Seidman JG . 3 . Maizel . Jacob V. . Leder . Philip . 24073515 .
• Bentley DL, Rabbits TH . Human immunoglobulin variable region genes--DNA sequences of two V kappa genes and a pseudogene . Nature . 288 . 5792 . 730–3 . 1981 . 6779204 . 10.1038/288730a0 . 4321131 .
• Huber C . The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ line . Eur. J. Immunol. . 23 . 11 . 2868–75 . 1993 . 8223863 . 10.1002/eji.1830231121 . vanc. Schäble KF . Huber E . 3 . Klein . Ralph . Meindl . Alfons . Thiebe . Rainer . Lamm . Rosemarie . Zachau . Hans G. . 85005411 .
• Olsen KE, Sletten K, Westermark P . Extended analysis of AL-amyloid protein from abdominal wall subcutaneous fat biopsy: kappa IV immunoglobulin light chain . Biochem. Biophys. Res. Commun. . 245 . 3 . 713–6 . 1998 . 9588180 . 10.1006/bbrc.1998.8515 .
• Wally J . Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic kappa1 light chain . Biochim. Biophys. Acta . 1454 . 1 . 49–56 . 1999 . 10354514 . 10.1016/s0925-4439(99)00019-8. vanc. Kica G . Zhang Y . 3 . Ericsson . T . Connors . LH . Benson . MD . Liepnieks . JJ . Murray . J . Skinner . M . free .
• Hotta K . Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8 . J. Mol. Biol. . 302 . 5 . 1213–25 . 2000 . 11183784 . 10.1006/jmbi.2000.4503 . vanc. Lange H . Tantillo DJ . 3 . Houk . K.N. . Hilvert . Donald . Wilson . Ian A. .
• Karpusas M . Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody . Structure . 9 . 4 . 321–9 . 2001 . 11525169 . 10.1016/S0969-2126(01)00590-1 . vanc. Lucci J . Ferrant J . 3 . Benjamin . Christopher . Taylor . Frederick R. . Strauch . Kathy . Garber . Ellen . Hsu . Yen-Ming . free .
• Davis DP . Both the environment and somatic mutations govern the aggregation pathway of pathogenic immunoglobulin light chain . J. Mol. Biol. . 313 . 5 . 1021–34 . 2001 . 11700059 . 10.1006/jmbi.2001.5092 . vanc. Gallo G . Vogen SM . 3 . Dul . JL . Sciarretta . KL . Kumar . A . Raffen . R . Stevens . FJ . Argon . Y .
• Pandey JP, Frederick M . TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis . Hum. Immunol. . 63 . 6 . 485–91 . 2002 . 12039524 . 10.1016/S0198-8859(02)00399-3 .

Notes and References

1. Web site: Entrez Gene: IGKC immunoglobulin kappa constant.