IGHV@ explained
Ig heavy chain V-III region VH26 is a protein that in humans is encoded by the IGHV@ gene.[1] [2] [3]
IGHV is the immunoglobulin heavy chain variable region genes; in B-cell neoplasms like chronic lymphocytic leukemia, mutations of IGHV are associated with better responses to some treatments and with prolonged survival.[4]
See also
Further reading
- Matsuda F, Shin EK, Hirabayashi Y, etal . Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments. . EMBO J. . 9 . 8 . 2501–6 . 1990 . 2114977 . 10.1002/j.1460-2075.1990.tb07429.x. 552279 .
- Cherif D, Berger R . New localizations of VH sequences by in situ hybridization with biotinylated probes. . Genes Chromosomes Cancer . 2 . 2 . 103–8 . 1991 . 2126193 . 10.1002/gcc.2870020205 . 22489747 .
- Toyonaga B, Yoshikai Y, Vadasz V, etal . Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain. . Proc. Natl. Acad. Sci. U.S.A. . 82 . 24 . 8624–8 . 1986 . 3866244 . 10.1073/pnas.82.24.8624 . 390970 . free .
- Matthyssens G, Rabbitts TH . Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region. . Proc. Natl. Acad. Sci. U.S.A. . 77 . 11 . 6561–5 . 1981 . 6450418 . 10.1073/pnas.77.11.6561 . 350325 . free .
- Mariette X, Tsapis A, Brouet JC . Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein. . Eur. J. Immunol. . 23 . 4 . 846–51 . 1993 . 7681398 . 10.1002/eji.1830230412 . 38756102 .
- Boursier L, Su W, Spencer J . Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments. . Mol. Immunol. . 39 . 16 . 1025–34 . 2003 . 12749909 . 10.1016/S0161-5890(03)00033-6 .
- Nakamura N, Nakamura S, Yamaguchi M, etal . CD5+ diffuse large B-cell lymphoma consists of germline cases and hypermutated cases in the immunoglobulin heavy chain gene variable region. . Int. J. Hematol. . 81 . 1 . 58–61 . 2005 . 15717690 . 10.1532/IJH97.04119 . 22639228 .
- Suárez E, Magadán S, Sanjuán I, etal . Rearrangement of only one human IGHV gene is sufficient to generate a wide repertoire of antigen specific antibody responses in transgenic mice. . Mol. Immunol. . 43 . 11 . 1827–35 . 2006 . 16343622 . 10.1016/j.molimm.2005.10.015 .
- Balogh Z, Reiniger L, Deák L, etal . IgVH gene mutation status and genomic imbalances in chronic lymphocytic leukaemia with increased prolymphocytes (CLL/PL). . Hematological Oncology . 25 . 2 . 90–5 . 2007 . 17410523 . 10.1002/hon.812 . 19587621 .
Notes and References
- Walter MA, Dosch HM, Cox DW . A deletion map of the human immunoglobulin heavy chain variable region . J Exp Med . 174 . 2 . 335–49 . Aug 1991 . 1649888 . 2118905 . 10.1084/jem.174.2.335 .
- Schroeder HW Jr . Walter MA . Hofker MH . Ebens A . Willems van Dijk K . Liao LC . Cox DW . Milner EC . Perlmutter RM . Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements . Proc Natl Acad Sci U S A . 85 . 21 . 8196–200 . Dec 1988 . 3141924 . 282394 . 10.1073/pnas.85.21.8196 . 1988PNAS...85.8196S . free .
- Web site: Entrez Gene: IGHV@ immunoglobulin heavy variable group.
- Forconi F, Sozzi E, Cencini E, etal . Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single agent cladribine and with more aggressive behavior. Blood. 114. 21. 4696–4702. November 2009. 19667403. 10.1182/blood-2009-03-212449. free.
