IGHM explained

Ig mu chain C region is a protein that in humans is encoded by the IGHM gene.^{[1] [2]}

It is associated with agammaglobulinemia-1.

Further reading

• Kristensen T, Lopez R, Prydz H . An estimate of the sequencing error frequency in the DNA sequence databases. . DNA Seq. . 2 . 6 . 343–6 . 1992 . 1446073 . 10.3109/10425179209020815 .
• Frutiger S, Hughes GJ, Paquet N, etal . Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M. . Biochemistry . 31 . 50 . 12643–7 . 1993 . 1472500 . 10.1021/bi00165a014 .
• Neale GA, Kitchingman GR . mRNA transcripts initiating within the human immunoglobulin mu heavy chain enhancer region contain a non-translatable exon and are extremely heterogeneous at the 5' end. . Nucleic Acids Res. . 19 . 9 . 2427–33 . 1991 . 1904154 . 10.1093/nar/19.9.2427 . 329453 .
• Tsubata T, Reth M . The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface. . J. Exp. Med. . 172 . 3 . 973–6 . 1990 . 2117639 . 10.1084/jem.172.3.973 . 2188549 .
• Dorai H, Gillies SD . The complete nucleotide sequence of a human immunoglobulin genomic C mu gene. . Nucleic Acids Res. . 17 . 15 . 6412 . 1989 . 2505237 . 10.1093/nar/17.15.6412 . 318311 .
• Pollok BA, Anker R, Eldridge P, etal . Molecular basis of the cell-surface expression of immunoglobulin mu chain without light chain in human B lymphocytes. . Proc. Natl. Acad. Sci. U.S.A. . 84 . 24 . 9199–203 . 1988 . 3122216 . 10.1073/pnas.84.24.9199 . 299720 . free .
• Putnam FW, Florent G, Paul C, etal . Complete amino acid sequence of the Mu heavy chain of a human IgM immunoglobulin. . Science . 182 . 4109 . 287–91 . 1973 . 4742735 . 10.1126/science.182.4109.287 . 1973Sci...182..287P . 30803888 .
• Watanabe S, Barnikol HU, Horn J, etal . [The primary structure of a monoclonal IgM-immunoglobulin (macroglobulin Gal.), II: the amino acid sequence of the H-chain (mu-type), subgroup H III. Architecture of the complete IgM-molecule (author's transl)] . Hoppe-Seyler's Z. Physiol. Chem. . 354 . 10–11 . 1505–9 . 1975 . 4803843 .
• Mihaesco E, Barnikol-Watanabe S, Barnikol HU, etal . The primary structure of the constant part of mu-chain-disease protein BOT. . Eur. J. Biochem. . 111 . 1 . 275–86 . 1981 . 6777162 . 10.1111/j.1432-1033.1980.tb06103.x . free .
• Dolby TW, Devuono J, Croce CM . Cloning and partial nucleotide sequence of human immunoglobulin mu chain cDNA from B cells and mouse-human hybridomas. . Proc. Natl. Acad. Sci. U.S.A. . 77 . 10 . 6027–31 . 1981 . 6777778 . 10.1073/pnas.77.10.6027 . 350206 . free .
• Rabbitts TH, Forster A, Milstein CP . Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch sequences. . Nucleic Acids Res. . 9 . 18 . 4509–24 . 1982 . 6795593 . 10.1093/nar/9.18.4509 . 327454 .
• Ohnishi K, Takemori T . Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines. . J. Biol. Chem. . 269 . 45 . 28347–53 . 1994 . 10.1016/S0021-9258(18)46934-7 . 7961773 . free .
• Harindranath N, Donadel G, Sigounas G, Notkins AL . Comparison of complete nucleotide sequence of the human IgM heavy chain constant region of polyreactive and monoreactive antibodies. . Mol. Immunol. . 30 . 1 . 111–2 . 1993 . 8417370 . 10.1016/0161-5890(93)90434-D .
• Donohoe ME, Blomberg BB . The 14.1 surrogate light chain promoter has lineage- and stage-restricted activity. . J. Immunol. . 158 . 4 . 1681–91 . 1997 . 10.4049/jimmunol.158.4.1681 . 9029104 . 29592657 .
• Li Q, Santini R, Rosenspire AR . Glycosylated extracellular domains of membrane immunoglobulin M contribute to its association with mb-1/B29 gene products and the B cell receptor complex. . Immunol. Invest. . 27 . 1–2 . 57–72 . 1998 . 9561918 . 10.3109/08820139809070890 .
• Paterson T, Innes J, McMillan L, etal . Variation in IgG1 heavy chain allotype does not contribute to differences in biological activity of two human anti-Rhesus (D) monoclonal antibodies. . Immunotechnology . 4 . 1 . 37–47 . 1998 . 9661813 . 10.1016/S1380-2933(98)00005-0 .
• Fang T, Smith BP, Roman CA . Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain maturation and surface expression. . J. Immunol. . 167 . 7 . 3846–57 . 2001 . 11564802 . 10.4049/jimmunol.167.7.3846. free .
• Taylor BJ, Pittman JA, Seeberger K, etal . Intraclonal homogeneity of clonotypic immunoglobulin M and diversity of nonclinical post-switch isotypes in multiple myeloma: insights into the evolution of the myeloma clone. . Clin. Cancer Res. . 8 . 2 . 502–13 . 2002 . 11839670 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .

Notes and References

1. Friedlander RM, Nussenzweig MC, Leder P . Complete nucleotide sequence of the membrane form of the human IgM heavy chain . Nucleic Acids Res . 18 . 14 . 4278 . Sep 1990 . 2115996 . 331217 . 10.1093/nar/18.14.4278 .
2. Web site: Entrez Gene: IGHM immunoglobulin heavy constant mu.