IGHG2 explained

Ig gamma-2 chain C region is a protein that in humans is encoded by the IGHG2 gene.^[1]

Further reading

• Connell GE, Parr DM, Hofmann T . The amino acid sequences of the three heavy chain constant region domains of a human IgG2 myeloma protein . Canadian Journal of Biochemistry . 57 . 6 . 758–67 . Jun 1979 . 113060 . 10.1139/o79-094 .
• Hofmann T, Parr DM . A note of the amino acid sequence of residues 381--391 of human immunoglobulins gamma chains . Molecular Immunology . 16 . 11 . 923–5 . Nov 1979 . 118920 . 10.1016/0161-5890(79)90091-9 .
• Milstein C, Frangione B . Disulphide bridges of the heavy chain of human immunoglobulin G2 . The Biochemical Journal . 121 . 2 . 217–25 . Jan 1971 . 4940472 . 1176558 . 10.1042/bj1210217.
• Frangione B, Milstein C, Pink JR . Structural studies of immunoglobulin G . Nature . 221 . 5176 . 145–8 . Jan 1969 . 5782707 . 10.1038/221145a0 . 4289483 .
• Ellison J, Buxbaum J, Hood L . Nucleotide sequence of a human immunoglobulin C gamma 4 gene . DNA . 1 . 1 . 11–8 . 1983 . 6299662 . 10.1089/dna.1.1981.1.11 .
• Ueda S, Nakai S, Nishida Y, Hisajima H, Honjo T . Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns . The EMBO Journal . 1 . 12 . 1539–44 . 1984 . 6327276 . 553248 . 10.1002/j.1460-2075.1982.tb01352.x.
• Krawinkel U, Rabbitts TH . Comparison of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 subclass genes . The EMBO Journal . 1 . 4 . 403–7 . 1984 . 6329676 . 553059 . 10.1002/j.1460-2075.1982.tb01182.x.
• Hisajima H, Nishida Y, Nakai S, Takahashi N, Ueda S, Honjo T . Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin . Proceedings of the National Academy of Sciences of the United States of America . 80 . 10 . 2995–9 . May 1983 . 6407005 . 393960 . 10.1073/pnas.80.10.2995 . free .
• Flanagan JG, Lefranc MP, Rabbitts TH . Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences . Cell . 36 . 3 . 681–8 . Mar 1984 . 6421489 . 10.1016/0092-8674(84)90348-9 . 54312675 .
• Wang AC, Tung E, Fudenberg HH . The primary structure of a human IgG2 heavy chain: genetic, evolutionary, and functional implications . Journal of Immunology . 125 . 3 . 1048–54 . Sep 1980 . 10.4049/jimmunol.125.3.1048 . 6774012 . free .
• Ellison J, Hood L . Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes . Proceedings of the National Academy of Sciences of the United States of America . 79 . 6 . 1984–8 . Mar 1982 . 6804948 . 346106 . 10.1073/pnas.79.6.1984 . 1982PNAS...79.1984E . free .
• Takahashi N, Ueda S, Obata M, Nikaido T, Nakai S, Honjo T . Structure of human immunoglobulin gamma genes: implications for evolution of a gene family . Cell . 29 . 2 . 671–9 . Jun 1982 . 6811139 . 10.1016/0092-8674(82)90183-0 . 31733882 . free .
• Stoppini M, Bellotti V, Negri A, Merlini G, Garver F, Ferri G . Characterization of the two unique human anti-flavin monoclonal immunoglobulins . European Journal of Biochemistry . 228 . 3 . 886–93 . Mar 1995 . 7737190 . 10.1111/j.1432-1033.1995.tb20336.x . 2024-05-12 .
• McLean GR, Nakouzi A, Casadevall A, Green NS . Human and murine immunoglobulin expression vector cassettes . Molecular Immunology . 37 . 14 . 837–45 . Oct 2000 . 11257305 . 10.1016/S0161-5890(00)00101-2 .
• Kristiansen TZ, Bunkenborg J, Gronborg M, Molina H, Thuluvath PJ, Argani P, Goggins MG, Maitra A, Pandey A . A proteomic analysis of human bile . Molecular & Cellular Proteomics . 3 . 7 . 715–28 . Jul 2004 . 15084671 . 10.1074/mcp.M400015-MCP200 . 15743023 . free .
• Jönsson G, Oxelius VA, Truedsson L, Braconier JH, Sturfelt G, Sjöholm AG . Homozygosity for the IgG2 subclass allotype G2M(n) protects against severe infection in hereditary C2 deficiency . Journal of Immunology . 177 . 1 . 722–8 . Jul 2006 . 16785571 . 10.4049/jimmunol.177.1.722 . free .
• Lee EB, Lee YJ, Shin DH, Choi YM, Park MH, Pandey JP, Song YW . Immunoglobulin GM and KM genotypes in Korean patients with systemic lupus erythematosus . Rheumatology International . 27 . 3 . 219–24 . Jan 2007 . 16944158 . 10.1007/s00296-006-0192-6 . 21100035 .

Notes and References

1. Web site: Entrez Gene: IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker).