IGHG1 explained

Ig gamma-1 chain C region is a protein that in humans is encoded by the IGHG1 gene.^[1]

Further reading

• Ponstingl H, Hilschmann N . [The rule of antibody structure. The primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie). III. The chymotryptic peptides of the H-chain, alignment of the tryptic peptides and discussion of the complete structure] . Hoppe-Seyler's Z. Physiol. Chem. . 357 . 11 . 1571–604 . 1977 . 10.1515/bchm2.1976.357.2.1571 . 826475 .
• Dreker L, Schwarz J, Reichel W, Hilschmann N . [Rule of antibody structure. the primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie), I: Purification and characterization of the protein, the L- and H-chains, the cyanogenbromide cleavage products, and the disulfide bridges (author's transl)] . Hoppe-Seyler's Z. Physiol. Chem. . 357 . 11 . 1515–40 . 1977 . 10.1515/bchm2.1976.357.2.1515 . 1002129 .
• Brady RL, Edwards DJ, Hubbard RE, etal . Crystal structure of a chimeric Fab' fragment of an antibody binding tumour cells. . J. Mol. Biol. . 227 . 1 . 253–64 . 1992 . 1522589 . 10.1016/0022-2836(92)90695-G .
• Gall WE, Edelman GM . The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds. . Biochemistry . 9 . 16 . 3188–96 . 1971 . 4923144 . 10.1021/bi00818a011 .
• Cunningham BA, Rutishauser U, Gall WE, etal . The covalent structure of a human gamma G-immunoglobulin. VII. Amino acid sequence of heavy-chain cyanogen bromide fragments H1-H4. . Biochemistry . 9 . 16 . 3161–70 . 1971 . 5489771 . 10.1021/bi00818a008 .
• Rutishauser U, Cunningham BA, Bennett C, etal . The covalent structure of a human gamma G-immunoglobulin. 8. Amino acid sequence of heavy-chain cyanogen bromide fragments H5-H7. . Biochemistry . 9 . 16 . 3171–81 . 1971 . 5530842 . 10.1021/bi00818a009 .
• Ellison JW, Berson BJ, Hood LE . The nucleotide sequence of a human immunoglobulin C gamma1 gene. . Nucleic Acids Res. . 10 . 13 . 4071–9 . 1982 . 6287432 . 10.1093/nar/10.13.4071 . 320779 .
• Takahashi N, Ueda S, Obata M, etal . Structure of human immunoglobulin gamma genes: implications for evolution of a gene family. . Cell . 29 . 2 . 671–9 . 1982 . 6811139 . 10.1016/0092-8674(82)90183-0 . 31733882 . free .
• Schmidt WE, Jung HD, Palm W, Hilschmann N . [Three-dimensional structure determination of antibodies. Primary structure of crystallized monoclonal immunoglobulin IgG1 KOL, I] . Hoppe-Seyler's Z. Physiol. Chem. . 364 . 6 . 713–47 . 1983 . 10.1515/bchm2.1983.364.1.713 . 6884994 .
• Deisenhofer J . Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution. . Biochemistry . 20 . 9 . 2361–70 . 1981 . 7236608 . 10.1021/bi00512a001 .
• Paterson T, Innes J, McMillan L, etal . Variation in IgG1 heavy chain allotype does not contribute to differences in biological activity of two human anti-Rhesus (D) monoclonal antibodies. . Immunotechnology . 4 . 1 . 37–47 . 1998 . 9661813 . 10.1016/S1380-2933(98)00005-0 .
• Masat L, Caldwell J, Armstrong R, etal . Association of SWAP-70 with the B cell antigen receptor complex. . Proc. Natl. Acad. Sci. U.S.A. . 97 . 5 . 2180–4 . 2000 . 10681448 . 10.1073/pnas.040374497 . 15774 . 2000PNAS...97.2180M . free .
• Sondermann P, Huber R, Oosthuizen V, Jacob U . The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex. . Nature . 406 . 6793 . 267–73 . 2000 . 10917521 . 10.1038/35018508 . 4306592 .
• Hotta K, Lange H, Tantillo DJ, etal . Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8. . J. Mol. Biol. . 302 . 5 . 1213–25 . 2000 . 11183784 . 10.1006/jmbi.2000.4503 .
• McLean GR, Nakouzi A, Casadevall A, Green NS . Human and murine immunoglobulin expression vector cassettes. . Mol. Immunol. . 37 . 14 . 837–45 . 2001 . 11257305 . 10.1016/S0161-5890(00)00101-2 .
• Karpusas M, Lucci J, Ferrant J, etal . Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody. . Structure . 9 . 4 . 321–9 . 2001 . 11525169 . 10.1016/S0969-2126(01)00590-1 . free .
• Mimura Y, Sondermann P, Ghirlando R, etal . Role of oligosaccharide residues of IgG1-Fc in Fc gamma RIIb binding. . J. Biol. Chem. . 276 . 49 . 45539–47 . 2002 . 11567028 . 10.1074/jbc.M107478200 . free.
• Pandey JP, Frederick M . TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis. . Hum. Immunol. . 63 . 6 . 485–91 . 2002 . 12039524 . 10.1016/S0198-8859(02)00399-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .

Notes and References

1. Web site: Entrez Gene: IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker).