IGHD explained

Ig delta chain C region is a protein that in humans is encoded by the IGHD gene.^{[1] [2]}

Further reading

• Shin SU, Wei CF, Amin AR, etal . Structural and functional properties of mouse-human chimeric IgD. . Hum. Antibodies Hybridomas . 3 . 2 . 65–74 . 1992 . 1633267 . 10.3233/HAB-1992-3202.
• Roes J, Rajewsky K . Cell autonomous expression of IgD is not essential for the maturation of conventional B cells. . Int. Immunol. . 3 . 12 . 1367–71 . 1992 . 1838007 . 10.1093/intimm/3.12.1367 .
• Shinoda T, Takahashi N, Takayasu T, etal . Complete amino acid sequence of the Fc region of a human delta chain . Proc. Natl. Acad. Sci. U.S.A. . 78 . 2 . 785–9 . 1981 . 6785754 . 10.1073/pnas.78.2.785 . 319887 . 1981PNAS...78..785S . free .
• Lin LC, Putnam FW . Primary structure of the Fc region of human immunoglobulin D: implications for evolutionary origin and biological function . Proc. Natl. Acad. Sci. U.S.A. . 78 . 1 . 504–8 . 1981 . 6787589 . 10.1073/pnas.78.1.504 . 319082 . 1981PNAS...78..504L . free .
• Putnam FW, Takahashi N, Tetaert D, etal . Amino acid sequence of the first constant region domain and the hinge region of the delta heavy chain of human IgD . Proc. Natl. Acad. Sci. U.S.A. . 78 . 10 . 6168–72 . 1982 . 6947220 . 10.1073/pnas.78.10.6168 . 348999 . free .
• Takayasu T, Takahashi N, Shinoda T . Amino acid sequence and location of the three glycopeptides in the Fc region of human immunoglobulin D . Biochem. Biophys. Res. Commun. . 97 . 2 . 635–41 . 1981 . 7008791 . 10.1016/0006-291X(80)90311-3 .
• Takayasu T, Suzuki S, Kametani F, etal . Amino acid sequence of galactosamine-containing glycopeptides in the hinge region of a human immunoglobulin D . Biochem. Biophys. Res. Commun. . 105 . 3 . 1066–71 . 1982 . 7092891 . 10.1016/0006-291X(82)91078-6 .
• Roes J, Rajewsky K . Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells . J. Exp. Med. . 177 . 1 . 45–55 . 1993 . 8418208 . 10.1084/jem.177.1.45 . 2190865 .
• Scott IC, Halila R, Jenkins JM, etal . Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1) . Gene . 174 . 1 . 135–43 . 1996 . 8863740 . 10.1016/0378-1119(96)00510-0 .
• Zupo S, Cutrona G, Mangiola M, Ferrarini M . Role of surface IgM and IgD on survival of the cells from B-cell chronic lymphocytic leukemia . Blood . 99 . 6 . 2277–8 . 2002 . 11902141 . 10.1182/blood-2001-11-0126 . free .
• Gala FA, Morrison SL . The role of constant region carbohydrate in the assembly and secretion of human IgD and IgA1 . J. Biol. Chem. . 277 . 32 . 29005–11 . 2002 . 12023968 . 10.1074/jbc.M203258200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Schamel WW, Kuppig S, Becker B, etal . A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum . Proc. Natl. Acad. Sci. U.S.A. . 100 . 17 . 9861–6 . 2003 . 12886015 . 10.1073/pnas.1633363100 . 187866 . 2003PNAS..100.9861S . free .
• Liu T, Qian WJ, Gritsenko MA, etal . Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry . J. Proteome Res. . 4 . 6 . 2070–80 . 2006 . 16335952 . 10.1021/pr0502065 . 1850943 .
• Lee CE, Gaëta B, Malming HR, etal . Reconsidering the human immunoglobulin heavy-chain locus: 1. An evaluation of the expressed human IGHD gene repertoire . Immunogenetics . 57 . 12 . 917–25 . 2006 . 16402215 . 10.1007/s00251-005-0062-5 . 29291806 .
• Lee CE, Jackson KJ, Sewell WA, Collins AM . Use of IGHJ and IGHD gene mutations in analysis of immunoglobulin sequences for the prognosis of chronic lymphocytic leukemia . Leuk. Res. . 31 . 9 . 1247–52 . 2007 . 17169423 . 10.1016/j.leukres.2006.10.013 .
• Samuelsson M, Hallström T, Forsgren A, Riesbeck K . Characterization of the IgD binding site of encapsulated Haemophilus influenzae serotype b . J. Immunol. . 178 . 10 . 6316–9 . 2007 . 17475860 . 10.4049/jimmunol.178.10.6316. free .

Notes and References

1. White MB, Shen AL, Word CJ, Tucker PW, Blattner FR . Human immunoglobulin D: genomic sequence of the delta heavy chain . Science . 228 . 4700 . 733–7 . May 1985 . 3922054 . 10.1126/science.3922054 .
2. Web site: Entrez Gene: IGHD immunoglobulin heavy constant delta.