IGFBP6 explained

Insulin-like growth factor-binding protein 6 (IGFBP-6) is a protein that in humans is encoded by the IGFBP6 gene.^{[1] [2] [3]}

Further reading

• Wood AW, Duan C, Bern HA . Insulin-like growth factor signaling in fish . Int. Rev. Cytol. . 243 . 215–85 . 2005 . 15797461 . 10.1016/S0074-7696(05)43004-1 . International Review of Cytology . 9780123646477 .
• Zapf J, Kiefer M, Merryweather J, etal . Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia . J. Biol. Chem. . 265 . 25 . 14892–8 . 1990 . 10.1016/S0021-9258(18)77200-1 . 1697583 . free .
• Kiefer MC, Masiarz FR, Bauer DM, Zapf J . Identification and molecular cloning of two new 30-kDa insulin-like growth factor binding proteins isolated from adult human serum . J. Biol. Chem. . 266 . 14 . 9043–9 . 1991 . 10.1016/S0021-9258(18)31549-7 . 1709161 . free .
• Shimasaki S, Gao L, Shimonaka M, Ling N . Isolation and molecular cloning of insulin-like growth factor-binding protein-6 . Mol. Endocrinol. . 5 . 7 . 938–48 . 1991 . 1719383 . 10.1210/mend-5-7-938 . free .
• Andress DL, Birnbaum RS . A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells . Biochem. Biophys. Res. Commun. . 176 . 1 . 213–8 . 1991 . 1850257 . 10.1016/0006-291X(91)90911-P .
• Martin JL, Willetts KE, Baxter RC . Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human fibroblasts . J. Biol. Chem. . 265 . 7 . 4124–30 . 1990 . 10.1016/S0021-9258(19)39711-X . 2154495 . free .
• Roghani M, Hossenlopp P, Lepage P, etal . Isolation from human cerebrospinal fluid of a new insulin-like growth factor-binding protein with a selective affinity for IGF-II . FEBS Lett. . 255 . 2 . 253–8 . 1989 . 2551732 . 10.1016/0014-5793(89)81101-9 . 22982971 . free .
• Ilvesmäki V, Blum WF, Voutilainen R . Insulin-like growth factor binding proteins in the human adrenal gland . Mol. Cell. Endocrinol. . 97 . 1–2 . 71–9 . 1994 . 7511544 . 10.1016/0303-7207(93)90212-3 . 22503525 .
• Kato M, Ishizaki A, Hellman U, etal . A human keratinocyte cell line produces two autocrine growth inhibitors, transforming growth factor-beta and insulin-like growth factor binding protein-6, in a calcium- and cell density-dependent manner . J. Biol. Chem. . 270 . 21 . 12373–9 . 1995 . 7539002 . 10.1074/jbc.270.21.12373 . free .
• Delhanty PJ, Hill DJ, Shimasaki S, Han VK . Insulin-like growth factor binding protein-4, -5 and -6 mRNAs in the human fetus: localization to sites of growth and differentiation? . Growth Regul. . 3 . 1 . 8–11 . 1993 . 7683540 .
• Bach LA, Hsieh S, Sakano K, etal . Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6 . J. Biol. Chem. . 268 . 13 . 9246–54 . 1993 . 10.1016/S0021-9258(18)98342-0 . 7683646 . free .
• Wegmann BR, Schöneberger HJ, Kiefer PE, etal . Molecular cloning of IGFBP-5 from SCLC cell lines and expression of IGFBP-4, IGFBP-5 and IGFBP-6 in lung cancer cell lines and primary tumours . Eur. J. Cancer . 29A . 11 . 1578–84 . 1993 . 7692907 . 10.1016/0959-8049(93)90298-T .
• Neumann GM, Marinaro JA, Bach LA . Identification of O-glycosylation sites and partial characterization of carbohydrate structure and disulfide linkages of human insulin-like growth factor binding protein 6 . Biochemistry . 37 . 18 . 6572–85 . 1998 . 9572875 . 10.1021/bi972894e .
• Neumann GM, Bach LA . The N-terminal disulfide linkages of human insulin-like growth factor-binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry . J. Biol. Chem. . 274 . 21 . 14587–94 . 1999 . 10329650 . 10.1074/jbc.274.21.14587 . free .
• Wong MS, Fong CC, Yang M . Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins . Biochim. Biophys. Acta . 1432 . 2 . 293–301 . 1999 . 10407151 . 10.1016/S0167-4838(99)00106-5 .
• Yu H, Mistry J, Nicar MJ, etal . Insulin-like growth factors (IGF-I, free IGF-I and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation . J. Clin. Lab. Anal. . 13 . 4 . 166–72 . 1999 . 10414596 . 10.1002/(SICI)1098-2825(1999)13:4<166::AID-JCLA5>3.0.CO;2-X . 6808158 .
• Dailly YP, Zhou Y, Linkhart TA, etal . Structure and characterization of the human insulin-like growth factor binding protein (IGFBP)-6 promoter: identification of a functional retinoid response element . Biochim. Biophys. Acta . 1518 . 1–2 . 145–51 . 2001 . 11267670 . 10.1016/S0167-4781(01)00192-0 .
• Weinzimer SA, Gibson TB, Collett-Solberg PF, etal . Transferrin is an insulin-like growth factor-binding protein-3 binding protein . J. Clin. Endocrinol. Metab. . 86 . 4 . 1806–13 . 2001 . 11297622 . 10.1210/jcem.86.4.7380 . free .

Notes and References

1. Kiefer MC, Ioh RS, Bauer DM, Zapf J . Molecular cloning of a new human insulin-like growth factor binding protein . Biochem Biophys Res Commun . 176 . 1 . 219–25 . May 1991 . 1850258 . 10.1016/0006-291X(91)90912-Q .
2. Ehrenborg E, Zazzi H, Lagercrantz S, Granqvist M, Hillerbrand U, Allander SV, Larsson C, Luthman H . Characterization and chromosomal localization of the human insulin-like growth factor-binding protein 6 gene . Mamm Genome . 10 . 4 . 376–80 . May 1999 . 10087296 . 10.1007/s003359901005 . 21499958 .
3. Web site: Entrez Gene: IGFBP6 insulin-like growth factor binding protein 6.