IGFBP5 explained

Insulin-like growth factor-binding protein 5 (IBF-5) is a protein that in humans is encoded by the IGFBP5 gene.^[1] An IGFBP5 gene was recently identified as being important for adaptation to varying water salinity in fish.^[2]

Further reading

• Mohan S, Farley JR, Baylink DJ . Age-related changes in IGFBP-4 and IGFBP-5 levels in human serum and bone: implications for bone loss with aging. . Prog. Growth Factor Res. . 6 . 2–4 . 465–73 . 1996 . 8817691 . 10.1016/0955-2235(95)00027-5 .
• Schneider MR, Wolf E, Hoeflich A, Lahm H . IGF-binding protein-5: flexible player in the IGF system and effector on its own . J. Endocrinol. . 172 . 3 . 423–40 . 2002 . 11874691 . 10.1677/joe.0.1720423 . free .
• Firth SM, Baxter RC . Cellular actions of the insulin-like growth factor binding proteins . Endocr. Rev. . 23 . 6 . 824–54 . 2003 . 12466191 . 10.1210/er.2001-0033 . free .
• Shimasaki S, Shimonaka M, Zhang HP, Ling N . Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human . J. Biol. Chem. . 266 . 16 . 10646–53 . 1991 . 10.1016/S0021-9258(18)99272-0 . 1709938 . free .
• Ehrenborg E, Vilhelmsdotter S, Bajalica S, etal . Structure and localization of the human insulin-like growth factor-binding protein 2 gene . Biochem. Biophys. Res. Commun. . 176 . 3 . 1250–5 . 1991 . 1710112 . 10.1016/0006-291X(91)90420-C .
• Andress DL, Birnbaum RS . A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells . Biochem. Biophys. Res. Commun. . 176 . 1 . 213–8 . 1991 . 1850257 . 10.1016/0006-291X(91)90911-P .
• Kiefer MC, Ioh RS, Bauer DM, Zapf J . Molecular cloning of a new human insulin-like growth factor binding protein . Biochem. Biophys. Res. Commun. . 176 . 1 . 219–25 . 1991 . 1850258 . 10.1016/0006-291X(91)90912-Q .
• Ilvesmäki V, Blum WF, Voutilainen R . Insulin-like growth factor binding proteins in the human adrenal gland . Mol. Cell. Endocrinol. . 97 . 1–2 . 71–9 . 1994 . 7511544 . 10.1016/0303-7207(93)90212-3 . 22503525 .
• Kou K, James PL, Clemmons DR, etal . Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11 . Genomics . 21 . 3 . 653–5 . 1994 . 7525452 . 10.1006/geno.1994.1329 .
• Andersson B, Wentland MA, Ricafrente JY, etal . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, etal . Large-Scale Concatenation cDNA Sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 .
• Nam TJ, Busby W, Clemmons DR . Insulin-like growth factor binding protein-5 binds to plasminogen activator inhibitor-I . Endocrinology . 138 . 7 . 2972–8 . 1997 . 9202242 . 10.1210/endo.138.7.5230 . free .
• Twigg SM, Baxter RC . Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit . J. Biol. Chem. . 273 . 11 . 6074–9 . 1998 . 9497324 . 10.1074/jbc.273.11.6074 . free .
• Zheng B, Clarke JB, Busby WH, etal . Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin . Endocrinology . 139 . 4 . 1708–14 . 1998 . 9528953 . 10.1210/endo.139.4.5945 . free .
• Twigg SM, Kiefer MC, Zapf J, Baxter RC . Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain . J. Biol. Chem. . 273 . 44 . 28791–8 . 1998 . 9786878 . 10.1074/jbc.273.44.28791 . free .
• Kalus W, Zweckstetter M, Renner C, etal . Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions . EMBO J. . 17 . 22 . 6558–72 . 1999 . 9822601 . 10.1093/emboj/17.22.6558 . 1171003 .
• Ständker L, Wobst P, Mark S, Forssmann WG . Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5 . FEBS Lett. . 441 . 2 . 281–6 . 1999 . 9883900 . 10.1016/S0014-5793(98)01497-5 . 23392744 . free .
• Kecha O, Martens H, Franchimont N, etal . Characterization of the insulin-like growth factor axis in the human thymus . J. Neuroendocrinol. . 11 . 6 . 435–40 . 1999 . 10336724 . 10.1046/j.1365-2826.1999.00343.x . 36605514 .

Notes and References

1. Allander SV, Larsson C, Ehrenborg E, Suwanichkul A, Weber G, Morris SL, Bajalica S, Kiefer MC, Luthman H, Powell DR . Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5 . J Biol Chem . 269 . 14 . 10891–8 . May 1994 . 10.1016/S0021-9258(17)34142-X . 7511611 . free .
2. Kusakabe M, Ishikawa A, Ravinet M, Yoshida K, Makino T, Toyoda A, Fujiyama A, Kitano J . Genetic basis for variation in salinity tolerance between stickleback ecotypes . Molecular Ecology . 26 . 1 . 304–319 . 2017 . 27706866 . 10.1111/mec.13875 . 2017MolEc..26..304K . 7821799 . free .