IGFBP2 explained

Insulin-like growth factor-binding protein 2 is a protein that in humans is encoded by the IGFBP2 gene.^[1]

Further reading

• Rajaram S, Baylink DJ, Mohan S . Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. . Endocr. Rev. . 18 . 6 . 801–31 . 1997 . 10.1210/edrv.18.6.0321 . 9408744 . free .
• Wolf E, Lahm H, Wu M, etal . Effects of IGFBP-2 overexpression in vitro and in vivo. . Pediatr. Nephrol. . 14 . 7 . 572–8 . 2000 . 10912521 . 10.1007/s004670000362 . 5823615 .
• Chesik D, De Keyser J, Wilczak N . Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis. . Cytokine Growth Factor Rev. . 18 . 3–4 . 267–78 . 2007 . 17485236 . 10.1016/j.cytogfr.2007.04.001 .
• Binkert C, Margot JB, Landwehr J, etal . Structure of the human insulin-like growth factor binding protein-2 gene . Mol. Endocrinol. . 6 . 5 . 826–36 . 1992 . 10.1210/mend.6.5.1376411 . 1376411 . 20288398 . free .
• Zhou J, Bondy C . Insulin-like growth factor-II and its binding proteins in placental development . Endocrinology . 131 . 3 . 1230–40 . 1992 . 1380437 . 10.1210/endo.131.3.1380437 .
• Ehrenborg E, Vilhelmsdotter S, Bajalica S, etal . Structure and localization of the human insulin-like growth factor-binding protein 2 gene . Biochem. Biophys. Res. Commun. . 176 . 3 . 1250–5 . 1991 . 1710112 . 10.1016/0006-291X(91)90420-C .
• Agarwal N, Hsieh CL, Sills D, etal . Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2) . Exp. Eye Res. . 52 . 5 . 549–61 . 1991 . 1712312 . 10.1016/0014-4835(91)90056-K . free .
• Roghani M, Lassarre C, Zapf J, etal . Two insulin-like growth factor (IGF)-binding proteins are responsible for the selective affinity for IGF-II of cerebrospinal fluid binding proteins . J. Clin. Endocrinol. Metab. . 73 . 3 . 658–66 . 1991 . 1714916 . 10.1210/jcem-73-3-658 .
• Clemmons DR, Snyder DK, Busby WH . Variables controlling the secretion of insulin-like growth factor binding protein-2 in normal human subjects . J. Clin. Endocrinol. Metab. . 73 . 4 . 727–33 . 1991 . 1716260 . 10.1210/jcem-73-4-727 .
• Roghani M, Segovia B, Whitechurch O, Binoux M . Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species . Growth Regul. . 1 . 3 . 125–30 . 1993 . 1726837 .
• Rosenfeld RG, Pham H, Conover CA, etal . Structural and immunological comparison of insulin-like growth factor binding proteins of cerebrospinal and amniotic fluids . J. Clin. Endocrinol. Metab. . 68 . 3 . 638–46 . 1989 . 2465304 . 10.1210/jcem-68-3-638 .
• Binkert C, Landwehr J, Mary JL, etal . Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2) . EMBO J. . 8 . 9 . 2497–502 . 1989 . 2479552 . 10.1002/j.1460-2075.1989.tb08386.x. 401241 .
• Ilvesmäki V, Blum WF, Voutilainen R . Insulin-like growth factor binding proteins in the human adrenal gland . Mol. Cell. Endocrinol. . 97 . 1–2 . 71–9 . 1994 . 7511544 . 10.1016/0303-7207(93)90212-3 . 22503525 .
• Zhou J, Bondy C . Anatomy of the human ovarian insulin-like growth factor system . Biol. Reprod. . 48 . 3 . 467–82 . 1993 . 7680905 . 10.1095/biolreprod48.3.467 . free .
• Han VK, Bassett N, Walton J, Challis JR . The expression of insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) genes in the human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface . J. Clin. Endocrinol. Metab. . 81 . 7 . 2680–93 . 1996 . 10.1210/jcem.81.7.8675597 . 8675597 . 33861826 . free .
• Bach LA, Rechler MM . Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography . Biochim. Biophys. Acta . 1313 . 1 . 79–88 . 1996 . 8781553 . 10.1016/0167-4889(96)00053-5 . free .
• Ho PJ, Baxter RC . Insulin-like growth factor-binding protein-2 in patients with prostate carcinoma and benign prostatic hyperplasia . Clin. Endocrinol. . 46 . 3 . 333–42 . 1997 . 9156044 . 10.1046/j.1365-2265.1997.1100922.x . 23145708 .
• Wong MS, Fong CC, Yang M . Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins . Biochim. Biophys. Acta . 1432 . 2 . 293–301 . 1999 . 10407151 . 10.1016/S0167-4838(99)00106-5.

Notes and References

1. Zapf J, Kiefer M, Merryweather J, Musiarz F, Bauer D, Born W, Fischer JA, Froesch ER . Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia . J Biol Chem . 265 . 25 . 14892–8 . Oct 1990 . 10.1016/S0021-9258(18)77200-1 . 1697583 . free .