IGF2BP3 explained

Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene.^{[1] [2] [3]}

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development.

The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.

See also

• IGF2BP1
• IGF2BP2

Further reading

• Yaniv K, Yisraeli JK . The involvement of a conserved family of RNA binding proteins in embryonic development and carcinogenesis . Gene . 287 . 1–2 . 49–54 . 2002 . 11992722 . 10.1016/S0378-1119(01)00866-6 .
• Yisraeli JK . VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins . Biol. Cell . 97 . 1 . 87–96 . 2005 . 15601260 . 10.1042/BC20040151 . 8767105 . free .
• Mueller-Pillasch F, Pohl B, Wilda M, etal . Expression of the highly conserved RNA binding protein KOC in embryogenesis . Mech. Dev. . 88 . 1 . 95–9 . 2000 . 10525192 . 10.1016/S0925-4773(99)00160-4 . 17091365 . free .
• Zhang JY, Chan EK, Peng XX, etal . Autoimmune responses to mRNA binding proteins p62 and Koc in diverse malignancies . Clin. Immunol. . 100 . 2 . 149–56 . 2001 . 11465943 . 10.1006/clim.2001.5048 .
• Monk D, Bentley L, Beechey C, etal . Characterisation of the growth regulating gene IMP3, a candidate for Silver-Russell syndrome . J. Med. Genet. . 39 . 8 . 575–81 . 2002 . 12161597 . 10.1136/jmg.39.8.575 . 1735212 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Scherer SW, Cheung J, MacDonald JR, etal . Human chromosome 7: DNA sequence and biology . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961 . 2003Sci...300..767S .
• Nielsen J, Adolph SK, Rajpert-De Meyts E, etal . Nuclear transit of human zipcode-binding protein IMP1 . Biochem. J. . 376 . Pt 2 . 383–91 . 2003 . 12921532 . 10.1042/BJ20030943 . 1223771 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Yantiss RK, Woda BA, Fanger GR, etal . KOC (K homology domain containing protein overexpressed in cancer): a novel molecular marker that distinguishes between benign and malignant lesions of the pancreas . Am. J. Surg. Pathol. . 29 . 2 . 188–95 . 2005 . 15644775 . 10.1097/01.pas.0000149688.98333.54. 23121446 .
• Liao B, Hu Y, Herrick DJ, Brewer G . The RNA-binding protein IMP-3 is a translational activator of insulin-like growth factor II leader-3 mRNA during proliferation of human K562 leukemia cells . J. Biol. Chem. . 280 . 18 . 18517–24 . 2005 . 15753088 . 10.1074/jbc.M500270200 . free .
• Hammer NA, Hansen TO, Byskov AG, etal . Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer . Reproduction . 130 . 2 . 203–12 . 2005 . 16049158 . 10.1530/rep.1.00664 . free .
• Feagins LA, Susnow N, Zhang HY, etal . Gain of allelic gene expression for IGF-II occurs frequently in Barrett's esophagus . Am. J. Physiol. Gastrointest. Liver Physiol. . 290 . 5 . G871–5 . 2006 . 16339295 . 10.1152/ajpgi.00383.2005 . 18680471 .
• Vikesaa J, Hansen TV, Jønson L, etal . RNA-binding IMPs promote cell adhesion and invadopodia formation . EMBO J. . 25 . 7 . 1456–68 . 2006 . 16541107 . 10.1038/sj.emboj.7601039 . 1440323 .
• Jiang Z, Chu PG, Woda BA, etal . Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study . Lancet Oncol. . 7 . 7 . 556–64 . 2006 . 16814207 . 10.1016/S1470-2045(06)70732-X .
• Li C, Rock KL, Woda BA, etal . IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression . Mod. Pathol. . 20 . 2 . 242–7 . 2007 . 17192788 . 10.1038/modpathol.3800735 . free .

Notes and References

1. Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC . A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development . Mol Cell Biol . 19 . 2 . 1262–70 . Feb 1999 . 9891060 . 116055 . 10.1128/MCB.19.2.1262.
2. Mueller-Pillasch F, Lacher U, Wallrapp C, Micha A, Zimmerhackl F, Hameister H, Varga G, Friess H, Buchler M, Beger HG, Vila MR, Adler G, Gress TM . Cloning of a gene highly overexpressed in cancer coding for a novel KH-domain containing protein . Oncogene . 14 . 22 . 2729–33 . Jul 1997 . 9178771 . 10.1038/sj.onc.1201110 . 838180 .
3. Web site: Entrez Gene: IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3.