IGF2-AS explained

IGF2 antisense RNA is a protein that in humans is encoded by the IGF2-AS gene.^[1]

Function

This gene is expressed in antisense to the insulin-like growth factor 2 (IGF2) gene and is imprinted and paternally expressed. It is thought to be non-coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay (NMD). Transcripts from this gene are produced in tumors and may function to suppress cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015].

Further reading

• Yang JM, Chen WS, Liu ZP, Luo YH, Liu WW . Effects of insulin-like growth factors-IR and -IIR antisense gene transfection on the biological behaviors of SMMC-7721 human hepatoma cells . J. Gastroenterol. Hepatol. . 18 . 3 . 296–301 . March 2003 . 12603530 . 10.1046/j.1440-1746.2003.02961.x. 24390333 .
• Devaney JM, Hoffman EP, Gordish-Dressman H, Kearns A, Zambraski E, Clarkson PM . IGF-II gene region polymorphisms related to exertional muscle damage . J. Appl. Physiol. . 102 . 5 . 1815–23 . May 2007 . 17289909 . 10.1152/japplphysiol.01165.2006 . 2136915 . 10.1.1.329.715 .
• Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q . Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway . Carcinogenesis . 29 . 10 . 1938–43 . October 2008 . 18676680 . 2722857 . 10.1093/carcin/bgn178 .
• Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q . Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China . Environ. Mol. Mutagen. . 50 . 4 . 285–90 . May 2009 . 19170196 . 2666781 . 10.1002/em.20452 . 2009EnvMM..50..285S .
• Hosgood HD, Menashe I, He X, Chanock S, Lan Q . PTEN identified as important risk factor of chronic obstructive pulmonary disease . Respir Med . 103 . 12 . 1866–70 . December 2009 . 19625176 . 2783799 . 10.1016/j.rmed.2009.06.016 .
• Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N . Genetic susceptibility to distinct bladder cancer subphenotypes . Eur. Urol. . 57 . 2 . 283–92 . February 2010 . 19692168 . 3220186 . 10.1016/j.eururo.2009.08.001 .
• Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, Muir K, Hopper JL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL, Stanford JL, Ostrander EA, Ingles SA, John EM, Thibodeau SN, Schaid D, Park JY, Spurdle A, Clements J, Dickinson JL, Maier C, Vogel W, Dörk T, Rebbeck TR, Cooney KA, Cannon-Albright L, Chappuis PO, Hutter P, Zeegers M, Kaneva R, Zhang HW, Lu YJ, Foulkes WD, English DR, Leongamornlert DA, Tymrakiewicz M, Morrison J, Ardern-Jones AT, Hall AL, O'Brien LT, Wilkinson RA, Saunders EJ, Page EC, Sawyer EJ, Edwards SM, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Southey MC, Lophatananon A, Liu JF, Kolonel LN, Le Marchand L, Wahlfors T, Tammela TL, Auvinen A, Lewis SJ, Cox A, FitzGerald LM, Koopmeiners JS, Karyadi DM, Kwon EM, Stern MC, Corral R, Joshi AD, Shahabi A, McDonnell SK, Sellers TA, Pow-Sang J, Chambers S, Aitken J, Gardiner RA, Batra J, Kedda MA, Lose F, Polanowski A, Patterson B, Serth J, Meyer A, Luedeke M, Stefflova K, Ray AM, Lange EM, Farnham J, Khan H, Slavov C, Mitkova A, Cao G, Easton DF . Identification of seven new prostate cancer susceptibility loci through a genome-wide association study . Nat. Genet. . 41 . 10 . 1116–21 . October 2009 . 19767753 . 2846760 . 10.1038/ng.450 .
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD . Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip . Am. J. Hum. Genet. . 85 . 5 . 628–42 . November 2009 . 19913121 . 2775832 . 10.1016/j.ajhg.2009.10.014 .
• McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF . Integrative predictive model of coronary artery calcification in atherosclerosis . Circulation . 120 . 24 . 2448–54 . December 2009 . 19948975 . 2810344 . 10.1161/CIRCULATIONAHA.109.865501 .

Notes and References

1. Web site: Entrez Gene: IGF2 antisense RNA. 2018-03-07.