IGBP1 explained

Immunoglobulin-binding protein 1 is a protein that in humans is encoded by the IGBP1 gene.^{[1] [2]}

Function

The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.^[2]

Interactions

IGBP1 has been shown to interact with PPP4C,^{[3] [4] [5]} PPP6C^{[4] [5]} and PPP2CA.^{[4] [5] [6] [7]}

Further reading

• Chen J, Peterson RT, Schreiber SL . Alpha 4 associates with protein phosphatases 2A, 4, and 6 . Biochemical and Biophysical Research Communications . 247 . 3 . 827–32 . Jun 1998 . 9647778 . 10.1006/bbrc.1998.8792 .
• Chung H, Nairn AC, Murata K, Brautigan DL . Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2 . Biochemistry . 38 . 32 . 10371–6 . Aug 1999 . 10441131 . 10.1021/bi990902g .
• Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ . Antigens recognized by autologous antibody in patients with renal-cell carcinoma . International Journal of Cancer . 83 . 4 . 456–64 . Nov 1999 . 10508479 . 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 . free .
• Liu J, Prickett TD, Elliott E, Meroni G, Brautigan DL . Phosphorylation and microtubule association of the Opitz syndrome protein mid-1 is regulated by protein phosphatase 2A via binding to the regulatory subunit alpha 4 . Proceedings of the National Academy of Sciences of the United States of America . 98 . 12 . 6650–5 . Jun 2001 . 11371618 . 34408 . 10.1073/pnas.111154698 . 2001PNAS...98.6650L . free .
• Short KM, Hopwood B, Yi Z, Cox TC . MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders . BMC Cell Biology . 3 . 1 . 2002 . 11806752 . 64779 . 10.1186/1471-2121-3-1 . free .
• Graham JM, Wheeler P, Tackels-Horne D, Lin AE, Hall BD, May M, Short KM, Schwartz CE, Cox TC . A new X-linked syndrome with agenesis of the corpus callosum, mental retardation, coloboma, micrognathia, and a mutation in the Alpha 4 gene at Xq13 . American Journal of Medical Genetics Part A . 123A . 1 . 37–44 . Nov 2003 . 14556245 . 10.1002/ajmg.a.20504 . 26545089 .
• Smetana JH, Oliveira CL, Jablonka W, Aguiar Pertinhez T, Carneiro FR, Montero-Lomeli M, Torriani I, Zanchin NI . Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42 . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics . 1764 . 4 . 724–34 . Apr 2006 . 16517231 . 10.1016/j.bbapap.2006.01.018 .

Notes and References

1. Onda M, Inui S, Maeda K, Suzuki M, Takahashi E, Sakaguchi N . Expression and chromosomal localization of the human alpha 4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the rapamycin-sensitive signal transduction pathway . Genomics . 46 . 3 . 373–8 . Dec 1997 . 9441740 . 10.1006/geno.1997.5048 .
2. Web site: Entrez Gene: IGBP1 immunoglobulin (CD79A) binding protein 1.
3. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC . PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 . The Journal of Biological Chemistry . 283 . 43 . 29273–84 . Oct 2008 . 18715871 . 2662017 . 10.1074/jbc.M803443200 . free .
4. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R . A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity . Molecular & Cellular Proteomics . 4 . 11 . 1725–40 . Nov 2005 . 16085932 . 10.1074/mcp.M500231-MCP200 . 7531012 . free .
5. Chen J, Peterson RT, Schreiber SL . Alpha 4 associates with protein phosphatases 2A, 4, and 6 . Biochemical and Biophysical Research Communications . 247 . 3 . 827–32 . Jun 1998 . 9647778 . 10.1006/bbrc.1998.8792 .
6. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC . A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein . Molecular & Cellular Proteomics . 8 . 1 . 157–71 . Jan 2009 . 18782753 . 2621004 . 10.1074/mcp.M800266-MCP200 . free .
7. Chung H, Nairn AC, Murata K, Brautigan DL . Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2 . Biochemistry . 38 . 32 . 10371–6 . Aug 1999 . 10441131 . 10.1021/bi990902g .