IFT74 explained

Intraflagellar transport protein 74 homolog (IFT74), also known as coiled-coil domain-containing protein 2 (CCDC2) and capillary morphogenesis gene 1 protein (CMG1), is a protein that in humans is encoded by the IFT74 gene.^{[1] [2]}

BCMG1 is upregulated by umbilical vein endothelial cells during capillary morphogenesis.^[2]

Further reading

• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Xiao S, Sato C, Kawarai T, etal . Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis. . Neurobiol. Aging . 29 . 8 . 1279–82 . 2008 . 17383054 . 10.1016/j.neurobiolaging.2007.02.022 . 10392826 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .

Notes and References

1. Web site: Entrez Gene: intraflagellar transport 74 homolog (Chlamydomonas).
2. Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA, Davis GE . Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling . J. Cell Sci. . 114 . Pt 15 . 2755–73 . August 2001 . 10.1242/jcs.114.15.2755 . 11683410 .