IFT57 explained

Intraflagellar transport protein 57 homolog is a protein that in humans is encoded by the IFT57 gene.^[1]

Interactions

IFT57 has been shown to interact with Caspase 8.^[2]

Further reading

• Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW . Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi . Nat. Cell Biol. . 4 . 2 . 95–105 . 2002 . 11788820 . 10.1038/ncb735 . 10439592 .
• Mattson MP . Accomplices to neuronal death . Nature . 415 . 6870 . 377–9 . 2002 . 11807533 . 10.1038/415377a . 39428123 .
• Cheng CM, Huang SP, Chang YF, Chung WY, Yuo CY . The viral death protein Apoptin interacts with Hippi, the protein interactor of Huntingtin-interacting protein 1 . Biochem. Biophys. Res. Commun. . 305 . 2 . 359–64 . 2003 . 12745083 . 10.1016/S0006-291X(03)00764-2 .
• Baker SA, Freeman K, Luby-Phelps K, Pazour GJ, Besharse JC . IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia . J. Biol. Chem. . 278 . 36 . 34211–8 . 2003 . 12821668 . 10.1074/jbc.M300156200 . free .
• Fan Y, Esmail MA, Ansley SJ, Blacque OE, Boroevich K, Ross AJ, Moore SJ, Badano JL, May-Simera H, Compton DS, Green JS, Lewis RA, van Haelst MM, Parfrey PS, Baillie DL, Beales PL, Katsanis N, Davidson WS, Leroux MR . Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome . Nat. Genet. . 36 . 9 . 989–93 . 2004 . 15314642 . 10.1038/ng1414 . free .
• Majumder P, Chattopadhyay B, Mazumder A, Das P, Bhattacharyya NP . Induction of apoptosis in cells expressing exogenous Hippi, a molecular partner of huntingtin-interacting protein Hip1 . Neurobiol. Dis. . 22 . 2 . 242–56 . 2006 . 16364650 . 10.1016/j.nbd.2005.11.003 . 23232258 .
• Banerjee M, Majumder P, Bhattacharyya NP, Dattagupta JK, Sen U . Cloning, expression, purification, crystallization and preliminary crystallographic analysis of pseudo death-effector domain of HIPPI, a molecular partner of Huntingtin-interacting protein HIP-1 . Acta Crystallographica Section F . 62 . Pt 12 . 1247–50 . 2006 . 17142908 . 2225382 . 10.1107/S1744309106046628 .
• Majumder P, Chattopadhyay B, Sukanya S, Ray T, Banerjee M, Mukhopadhyay D, Bhattacharyya NP . Interaction of HIPPI with putative promoter sequence of caspase-1 in vitro and in vivo . Biochem. Biophys. Res. Commun. . 353 . 1 . 80–5 . 2007 . 17173859 . 10.1016/j.bbrc.2006.11.138 .

Notes and References

1. Web site: Entrez Gene: IFT57 intraflagellar transport 57 homolog (Chlamydomonas).
2. Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW . Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi . Nat. Cell Biol. . 4 . 2 . 95–105 . Feb 2002 . 11788820 . 10.1038/ncb735 . 10439592 .