IFNK explained

Interferon kappa, also known as IFN-kappa, is a protein that in humans is encoded by the IFNK gene.^{[1] [2] [3]}

Function

IFN-kappa is a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster.^[1]

References

3.Antiviral activity of transiently expressed IFN-kappa is cell-associated. Buontempo, P.J., Jubin, R.G., Buontempo, C.A., Wagner, N.E., Reyes, G.R., Baroudy, B.M. J. Interferon Cytokine Res. (2006) [Pubmed]

Further reading

• Liu C, Batliwalla F, Li W, etal . Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis . Mol. Med. . 14 . 9–10 . 575–81 . 2008. 18615156 . 10.2119/2008-00056.Liu . 2443997.
• DeCarlo CA, Severini A, Edler L, etal . IFN-κ, a novel type I IFN, is undetectable in HPV-positive human cervical keratinocytes. . Lab. Invest. . 90 . 10 . 1482–91 . 2010 . 20479716 . 10.1038/labinvest.2010.95 . free .
• Silva LK, Blanton RE, Parrado AR, etal . Dengue hemorrhagic fever is associated with polymorphisms in JAK1. . Eur. J. Hum. Genet. . 18 . 11 . 1221–7 . 2010 . 20588308 . 10.1038/ejhg.2010.98 . 2950898.
• Yang XR, Liang X, Pfeiffer RM, etal . Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. . Fam. Cancer . 9 . 4 . 625–33 . 2010 . 20574843 . 10.1007/s10689-010-9356-3 . 3233727.
• Ferreira RC, Pan-Hammarström Q, Graham RR . Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. . Nat. Genet. . 42 . 9 . 777–80 . 2010 . 20694011 . 10.1038/ng.644 . 205356843 . etal.
• Laaksovirta H, Peuralinna T, Schymick JC, etal . Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study. . Lancet Neurol . 9 . 10 . 978–85 . 2010 . 20801718 . 10.1016/S1474-4422(10)70184-8 . 2965392.
• Clark HF, Gurney AL, Abaya E, etal . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697.
• Rincon-Orozco B, Halec G, Rosenberger S, etal . Epigenetic silencing of interferon-kappa in human papillomavirus type 16-positive cells. . Cancer Res. . 69 . 22 . 8718–25 . 2009 . 19887612 . 10.1158/0008-5472.CAN-09-0550 . free .
• Humphray SJ, Oliver K, Hunt AR, etal . DNA sequence and analysis of human chromosome 9. . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081. 2004Natur.429..369H .
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites. . Protein Sci. . 13 . 10 . 2819–24 . 2004 . 15340161 . 10.1110/ps.04682504 . 2286551.
• van Es MA, Veldink JH, Saris CG, etal . Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. . Nat. Genet. . 41 . 10 . 1083–7 . 2009 . 19734901 . 10.1038/ng.442 . 8659710 .
• Harley IT, Niewold TB, Stormont RM, etal . The role of genetic variation near interferon-kappa in systemic lupus erythematosus . J. Biomed. Biotechnol. . 2010 . 1–11. 2010 . 20706608 . 10.1155/2010/706825 . 2914299. free .

Notes and References

1. Web site: Entrez Gene: interferon.
2. LaFleur DW, Nardelli B, Tsareva T, Mather D, Feng P, Semenuk M, Taylor K, Buergin M, Chinchilla D, Roshke V, Chen G, Ruben SM, Pitha PM, Coleman TA, Moore PA . Interferon-kappa, a novel type I interferon expressed in human keratinocytes . J. Biol. Chem. . 276 . 43 . 39765–71 . October 2001 . 11514542 . 10.1074/jbc.M102502200 . free .
3. Nardelli B, Zaritskaya L, Semenuk M, Cho YH, LaFleur DW, Shah D, Ullrich S, Girolomoni G, Albanesi C, Moore PA . Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system . J. Immunol. . 169 . 9 . 4822–30 . November 2002 . 12391192 . 10.4049/jimmunol.169.9.4822. free .