IFNB1 explained

Interferon beta is a protein that in humans is encoded by the IFNB1 gene.^[1] The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.

Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.

Further reading

• Book: Biron CA, Nguyen KB, Pien GC . Innate Immune Responses to LCMV Infections: Natural Killer Cells and Cytokines . Arenaviruses II . Curr. Top. Microbiol. Immunol. . 263 . 7–27 . 2002 . 11987821 . 10.1007/978-3-642-56055-2_2. Current Topics in Microbiology and Immunology . 978-3-642-62724-8 .
• Conti L, Fantuzzi L, Del Cornò M, etal . Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis. . Immunobiology . 209 . 1–2 . 99–115 . 2005 . 15481145 . 10.1016/j.imbio.2004.02.008 .
• Bekisz J, Schmeisser H, Hernandez J, etal . Human interferons alpha, beta and omega . Growth Factors . 22 . 4 . 243–51 . 2005 . 15621727 . 10.1080/08977190400000833 . 84918367 .
• Copeland KF . Modulation of HIV-1 transcription by cytokines and chemokines . Mini Reviews in Medicinal Chemistry . 5 . 12 . 1093–101 . 2006 . 16375755 . 10.2174/138955705774933383 .
• Silverman RH, Sengupta DN . Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes . J. Exp. Pathol. . 5 . 2 . 69–77 . 1991 . 1708818 .
• Flores I, Mariano TM, Pestka S . Human interferon omega (omega) binds to the alpha/beta receptor . J. Biol. Chem. . 266 . 30 . 19875–7 . 1991 . 10.1016/S0021-9258(18)54862-6 . 1834641 . free .
• May LT, Sehgal PB . On the relationship between human interferon alpha 1 and beta 1 genes . J. Interferon Res. . 5 . 3 . 521–6 . 1985 . 2414376 . 10.1089/jir.1985.5.521.
• Francois DT, Katona IM, June CH, etal . Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens . Clin. Immunol. Immunopathol. . 48 . 3 . 297–306 . 1988 . 3135963 . 10.1016/0090-1229(88)90023-2 .
• Conradt HS, Egge H, Peter-Katalinic J, etal . Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line . J. Biol. Chem. . 262 . 30 . 14600–5 . 1987 . 10.1016/S0021-9258(18)47838-6 . 3667593 . free .
• Blank KJ, McKernan LN, Murasko DM . Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation . J. Interferon Res. . 5 . 1 . 215–21 . 1985 . 3872918 . 10.1089/jir.1985.5.215.
• Derynck R, Content J, DeClercq E, etal . Isolation and structure of a human fibroblast interferon gene . Nature . 285 . 5766 . 542–7 . 1980 . 6157094 . 10.1038/285542a0 . 1980Natur.285..542D . 4272787 .
• Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M . The nucleotide sequence of human fibroblast interferon cDNA . Gene . 10 . 1 . 11–5 . 1980 . 6157601 . 10.1016/0378-1119(80)90138-9 .
• Houghton M, Easton MA, Stewart AG, etal . The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase . Nucleic Acids Res. . 8 . 13 . 2885–94 . 1981 . 6159580 . 10.1093/nar/8.13.2885 . 324132 .
• Goeddel DV, Shepard HM, Yelverton E, etal . Synthesis of human fibroblast interferon by E. coli . Nucleic Acids Res. . 8 . 18 . 4057–74 . 1981 . 6159584 . 10.1093/nar/8.18.4057 . 324219 .
• Houghton M, Stewart AG, Doel SM, etal . The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers . Nucleic Acids Res. . 8 . 9 . 1913–31 . 1981 . 6159597 . 10.1093/nar/8.9.1913 . 324047 .
• Wetzel R . Assignment of the disulphide bonds of leukocyte interferon . Nature . 289 . 5798 . 606–7 . 1981 . 6162107 . 10.1038/289606a0 . 1981Natur.289..606W . 4327734 .
• Lawn RM, Adelman J, Franke AE, etal . Human fibroblast interferon gene lacks introns . Nucleic Acids Res. . 9 . 5 . 1045–52 . 1981 . 6164984 . 10.1093/nar/9.5.1045 . 326735 .
• Shepard HM, Leung D, Stebbing N, Goeddel DV . A single amino acid change in IFN-beta1 abolishes its antiviral activity . Nature . 294 . 5841 . 563–5 . 1982 . 6171735 . 10.1038/294563a0 . 4344841 .
• Content J, De Wit L, Pierard D, etal . Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta . Proc. Natl. Acad. Sci. U.S.A. . 79 . 9 . 2768–72 . 1982 . 6178110 . 10.1073/pnas.79.9.2768 . 346287 . 1982PNAS...79.2768C . free .
• Fiers W, Remaut E, Devos R, etal . The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells . Philos. Trans. R. Soc. Lond. B Biol. Sci. . 299 . 1094 . 29–38 . 1983 . 6183692 . 10.1098/rstb.1982.0103 .

Notes and References

1. Web site: Entrez Gene: IFNB1 interferon, beta 1, fibroblast.