IFNA7 explained

Interferon alpha-7 is a protein that in humans is encoded by the IFNA7 gene.^{[1] [2]}

Further reading

• Conti L, Fantuzzi L, Del Cornò M, etal . Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis. . Immunobiology . 209 . 1–2 . 99–115 . 2005 . 15481145 . 10.1016/j.imbio.2004.02.008 .
• Capobianchi MR, Ankel H, Ameglio F, etal . Recombinant glycoprotein 120 of human immunodeficiency virus is a potent interferon inducer . AIDS Res. Hum. Retroviruses . 8 . 5 . 575–9 . 1992 . 1381203 . 10.1089/aid.1992.8.575 .
• Tyring SK, Cauda R, Tumbarello M, etal . Synthetic peptides corresponding to sequences in HIV envelope gp41 and gp120 enhance in vitro production of interleukin-1 and tumor necrosis factor but depress production of interferon-alpha, interferon-gamma and interleukin-2 . Viral Immunol. . 4 . 1 . 33–42 . 1991 . 1905933 . 10.1089/vim.1991.4.33 .
• Stine KC, Bolognesi D, Weinhold KJ . Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity . Journal of Biological Response Modifiers . 8 . 5 . 501–10 . 1989 . 2552026 .
• Cohen S, Velan B, Grosfeld H, etal . Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells . Dev. Biol. Stand. . 60 . 111–22 . 1985 . 2995168 .
• Henco K, Brosius J, Fujisawa A, etal . Structural relationship of human interferon alpha genes and pseudogenes . J. Mol. Biol. . 185 . 2 . 227–60 . 1985 . 4057246 . 10.1016/0022-2836(85)90401-2 .
• Ullrich A, Gray A, Goeddel DV, Dull TJ . Nucleotide sequence of a portion of human chromosome 9 containing a leukocyte interferon gene cluster . J. Mol. Biol. . 156 . 3 . 467–86 . 1982 . 6181262 . 10.1016/0022-2836(82)90261-3 .
• Ameglio F, Capobianchi MR, Castilletti C, etal . Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear cells; correlation with the induction of other cytokines . Clin. Exp. Immunol. . 95 . 3 . 455–8 . 1994 . 7511078 . 10.1111/j.1365-2249.1994.tb07018.x. 1535081 .
• Ankel H, Capobianchi MR, Castilletti C, Dianzani F . Interferon induction by HIV glycoprotein 120: role of the V3 loop . Virology . 205 . 1 . 34–43 . 1994 . 7526537 . 10.1006/viro.1994.1617 .
• Nair MP, Chadha KC, Stadler I, etal . Differential effects of human immunodeficiency virus type 1 envelope protein gp120 on interferon production by mononuclear cells from adults and neonates . Clin. Diagn. Lab. Immunol. . 2 . 4 . 434–8 . 1995 . 7583919 . 10.1128/CDLI.2.4.434-438.1995. 170174 .
• Borghi P, Fantuzzi L, Varano B, etal . Induction of interleukin-10 by human immunodeficiency virus type 1 and its gp120 protein in human monocytes/macrophages . J. Virol. . 69 . 2 . 1284–7 . 1995 . 7815507 . 10.1128/JVI.69.2.1284-1287.1995. 188705 .
• Capobianchi MR, Ameglio F, Cordiali Fei P, etal . Coordinate induction of interferon alpha and gamma by recombinant HIV-1 glycoprotein 120 . AIDS Res. Hum. Retroviruses . 9 . 10 . 957–62 . 1994 . 7904170 . 10.1089/aid.1993.9.957 .
• Chen YH, Böck G, Vornhagen R, etal . HIV-1 gp41 enhances major histocompatibility complex class I and ICAM-1 expression on H9 and U937 cells . Int. Arch. Allergy Immunol. . 104 . 3 . 227–31 . 1994 . 7913356 . 10.1159/000236670 .
• Francis ML, Meltzer MS . Induction of IFN-alpha by HIV-1 in monocyte-enriched PBMC requires gp120-CD4 interaction but not virus replication . J. Immunol. . 151 . 4 . 2208–16 . 1993 . 10.4049/jimmunol.151.4.2208 . 8345204 .
• Shirazi Y, Pitha PM . Interferon alpha-mediated inhibition of human immunodeficiency virus type 1 provirus synthesis in T-cells . Virology . 193 . 1 . 303–12 . 1993 . 8438572 . 10.1006/viro.1993.1126 . free .
• Ankel H, Capobianchi MR, Frezza F, etal . Interferon induction by HIV-1-infected cells: a possible role of sulfatides or related glycolipids . Virology . 221 . 1 . 113–9 . 1996 . 8661419 . 10.1006/viro.1996.0357 . free .
• Tiefenbrun N, Melamed D, Levy N, etal . Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest . Mol. Cell. Biol. . 16 . 7 . 3934–44 . 1996 . 8668211 . 10.1128/MCB.16.7.3934. 231390 .
• Schols D, De Clercq E . Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production . J. Virol. . 70 . 8 . 4953–60 . 1996 . 8764000 . 10.1128/JVI.70.8.4953-4960.1996. 190447 .
• Hussain M, Gill DS, Liao MJ . Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population . J. Interferon Cytokine Res. . 16 . 10 . 853–9 . 1997 . 8910771 . 10.1089/jir.1996.16.853 .

Notes and References

1. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO . Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia . Genomics . 14 . 2 . 437–43 . Dec 1992 . 1385305 . 10.1016/S0888-7543(05)80238-1 .
2. Web site: Entrez Gene: IFNA7 interferon, alpha 7.