IFNA16 explained

Interferon alpha-16, also known as IFN-alpha-16, is a protein that in humans is encoded by theIFNA16 gene.^{[1] [2]}

Further reading

• Shirazi Y, Pitha PM . Interferon alpha-mediated inhibition of human immunodeficiency virus type 1 provirus synthesis in T-cells . Virology . 193 . 1 . 303–12 . 1993 . 8438572 . 10.1006/viro.1993.1126 . free .
• Chen YH . HIV-1 gp41 enhances major histocompatibility complex class I and ICAM-1 expression on H9 and U937 cells . Int. Arch. Allergy Immunol. . 104 . 3 . 227–31 . 1994 . 7913356 . 10.1159/000236670 . Böck G . Vornhagen R . Steindl . Franz . Katinger . Hermann . Dierich . Manfred P..
• Dianzani F . Effects of IFN alpha on late stages of HIV-1 replication cycle . Biochimie . 80 . 8–9 . 745–54 . 1998. 9865497 . 10.1016/S0300-9084(99)80028-5 . Castilletti C . Gentile M . Gelderblom . HR . Frezza . F . Capobianchi . MR .
• Zagury JF . Are CD4 and Fas peptide identities of gp120 relevant to the molecular basis of AIDS pathogenesis? . Cell Death Differ. . 2 . 1 . 23–32 . 1995 . 17180012 . Chams V . Lachgar A . Achour . A . Bizzini . B . Burny . A . Zagury . D . Feldman . M .
• Myers MP . TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B . J. Biol. Chem. . 276 . 51 . 47771–4 . 2001 . 11694501 . 10.1074/jbc.C100583200 . Andersen JN . Cheng A . Tremblay . ML . Horvath . CM . Parisien . JP . Salmeen . A . Barford . D . Tonks . NK . free .
• Cicala C . HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication . Proc. Natl. Acad. Sci. U.S.A. . 99 . 14 . 9380–5 . 2002 . 12089333 . 10.1073/pnas.142287999 . 123149 . Arthos J . Selig SM . Dennis Jr . G . Hosack . DA . Van Ryk . D . Spangler . ML . Steenbeke . TD . Khazanie . P. 2002PNAS...99.9380C . free .
• Schmidt B . HIV-infected cells are major inducers of plasmacytoid dendritic cell interferon production, maturation, and migration . Virology . 343 . 2 . 256–66 . 2005 . 16278001 . 10.1016/j.virol.2005.09.059 . Ashlock BM . Foster H . Fujimura . Sue H. . Levy . Jay A. .
• Kinzl P, Otani T, Benz R, Minowada J . Interferon-alpha and -gamma differentially reduce rapid immature T-cell death by contact with HIV-1 carrier cell clones in vitro . Microbiol. Immunol. . 41 . 9 . 709–16 . 1997 . 9343822 . 10.1111/j.1348-0421.1997.tb01915.x. 85304106 . free .
• Francis ML, Meltzer MS . Induction of IFN-alpha by HIV-1 in monocyte-enriched PBMC requires gp120-CD4 interaction but not virus replication . J. Immunol. . 151 . 4 . 2208–16 . 1993 . 10.4049/jimmunol.151.4.2208 . 8345204 .
• Peng G . Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity . J. Exp. Med. . 203 . 1 . 41–6 . 2006 . 16418394 . 10.1084/jem.20051512 . Lei KJ . Jin W . Greenwell-Wild . T . Wahl . SM . 2118075 .
• Silva LK . Dengue hemorrhagic fever is associated with polymorphisms in JAK1 . Eur. J. Hum. Genet. . 18 . 11 . 1221–7 . 2010 . 20588308 . 10.1038/ejhg.2010.98 . 2950898 . Blanton RE . Parrado AR . Melo . Paulo S . Morato . Vanessa G . Reis . Eliana AG . Dias . Juarez P . Castro . Jesuina M . Vasconcelos . Pedro FC.
• Yang XR . Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations . Fam. Cancer . 9 . 4 . 625–33 . 2010 . 20574843 . 10.1007/s10689-010-9356-3 . Liang X . Pfeiffer RM . Wheeler . William . Maeder . Dennis . Burdette . Laurie . Yeager . Meredith . Chanock . Stephen . Tucker . Margaret A. . 3233727.
• Popik W, Hesselgesser JE, Pitha PM . Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway . J. Virol. . 72 . 8 . 6406–13 . 1998 . 9658081 . 10.1128/JVI.72.8.6406-6413.1998. 109793.
• Gessani S . Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation . J. Leukoc. Biol. . 62 . 1 . 49–53 . 1997 . 9225992 . 10.1002/jlb.62.1.49. Borghi P . Fantuzzi L . Varano . B . Conti . L . Puddu . P . Belardelli . F . 31546644 . free.
• Del Cornò M . Human immunodeficiency virus type 1 gp120 and other activation stimuli are highly effective in triggering alpha interferon and CC chemokine production in circulating plasmacytoid but not myeloid dendritic cells . J. Virol. . 79 . 19 . 12597–601 . 2005 . 16160188 . 10.1128/JVI.79.19.12597-12601.2005 . Gauzzi MC . Penna G . Belardelli . F. . Adorini . L. . Gessani . S. . 1211530 .
• Sen GC, Lengyel P . The interferon system. A bird's eye view of its biochemistry . J. Biol. Chem. . 267 . 8 . 5017–20 . 1992 . 10.1016/S0021-9258(18)42719-6 . 1371992 . free .
• Taoufik Y . Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect . Blood . 89 . 8 . 2842–8 . 1997 . 9108403 . 10.1182/blood.V89.8.2842. Lantz O . Wallon C . Charles . A . Dussaix . E . Delfraissy . JF . free.
• Conti L . Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis . Immunobiology . 209 . 1–2 . 99–115 . 2004 . 15481145 . 10.1016/j.imbio.2004.02.008 . Fantuzzi L . Del Cornò M . Belardelli . Filippo . Gessani . Sandra.
• Schols D, De Clercq E . Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production . J. Virol. . 70 . 8 . 4953–60 . 1996 . 8764000 . 10.1128/JVI.70.8.4953-4960.1996. 190447.
• Ankel H . Interferon induction by HIV-1-infected cells: a possible role of sulfatides or related glycolipids . Virology . 221 . 1 . 113–9 . 1996 . 8661419 . 10.1006/viro.1996.0357 . Capobianchi MR . Frezza F . Castilletti . C . Dianzani . F . free .

Notes and References

1. Web site: Entrez Gene: interferon.
2. Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO . Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia . Genomics . 14 . 2 . 437–43 . October 1992 . 1385305 . 10.1016/S0888-7543(05)80238-1.