IFN1@ explained

Interferon, type 1, cluster, also known as IFN1@, is a human gene.^[1]

Further reading

• Ferrantini M, Capone I, Belardelli F . Interferon-alpha and cancer: mechanisms of action and new perspectives of clinical use. . Biochimie . 89 . 6–7 . 884–93 . 2007 . 17532550 . 10.1016/j.biochi.2007.04.006 .
• Nagata S, Mantei N, Weissmann C . The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha . Nature . 287 . 5781 . 401–8 . 1981 . 6159536 . 10.1038/287401a0. 29500779 .
• Radaeva S, Jaruga B, Kim WH, etal . Interferon-gamma inhibits interferon-alpha signalling in hepatic cells: evidence for the involvement of STAT1 induction and hyperexpression of STAT1 in chronic hepatitis C . Biochem. J. . 379 . Pt 1 . 199–208 . 2004 . 14690454 . 10.1042/BJ20031495 . 1224051 .
• Tecchio C, Huber V, Scapini P, etal . IFNalpha-stimulated neutrophils and monocytes release a soluble form of TNF-related apoptosis-inducing ligand (TRAIL/Apo-2 ligand) displaying apoptotic activity on leukemic cells . Blood . 103 . 10 . 3837–44 . 2004 . 14726404 . 10.1182/blood-2003-08-2806 . 22297033 . free .
• Wieczorek S, Dahmen N, Kasten M, etal . A rare form of narcolepsy (HLA-DR2-) shows possible association with (functionally relevant) alpha-interferon gene polymorphisms . Psychiatr. Genet. . 14 . 1 . 47–51 . 2004 . 15091316 . 10.1097/00041444-200403000-00008 . 13012910 .
• Mihm S, Frese M, Meier V, etal . Interferon type I gene expression in chronic hepatitis C . Lab. Invest. . 84 . 9 . 1148–59 . 2004 . 15208644 . 10.1038/labinvest.3700135 . free .
• Palucka AK, Blanck JP, Bennett L, etal . Cross-regulation of TNF and IFN-α in autoimmune diseases . Proc. Natl. Acad. Sci. U.S.A. . 102 . 9 . 3372–7 . 2005 . 15728381 . 10.1073/pnas.0408506102 . 552921 . 2005PNAS..102.3372P . free .
• Zhao KW, Li D, Zhao Q, etal . Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK . J. Biol. Chem. . 280 . 52 . 42707–14 . 2006 . 16260419 . 10.1074/jbc.M506178200 . free .
• Civas A, Génin P, Morin P, etal . Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon . J. Biol. Chem. . 281 . 8 . 4856–66 . 2006 . 16380379 . 10.1074/jbc.M506812200 . free .
• Gómez-Benito M, Balsas P, Carvajal-Vergara X, etal . Mechanism of apoptosis induced by IFN-alpha in human myeloma cells: role of Jak1 and Bim and potentiation by rapamycin . Cell. Signal. . 19 . 4 . 844–54 . 2007 . 17158029 . 10.1016/j.cellsig.2006.10.009 .
• Rajeswari DN, Selvaraj P, Raghavan S, etal . Influence of HLA-DR2 on perforin-positive cells in pulmonary tuberculosis . International Journal of Immunogenetics . 34 . 5 . 379–84 . 2007 . 17845310 . 10.1111/j.1744-313X.2007.00703.x . 31073749 .
• Karauzum SB, Yasar D, Dirice E, etal . Lack of BCL-2 confers interferon-alpha sensitivity to B-cell lymphomas . Growth Factors . 25 . 2 . 94–100 . 2007 . 17852408 . 10.1080/08977190701345515 . 30719569 .

Notes and References

1. Web site: Entrez Gene: IFN1@ interferon, type 1, cluster.