IFIT3 explained

Interferon-induced protein with tetratricopeptide repeats 3, also known as interferon-stimulated gene 49 (ISG49),^[1] is a protein that in humans is encoded by the IFIT3 gene.^{[1] [2] [3] [4]} It plays a part in the innate immune response to viruses in response to type I interferon signaling.^[1]

Further reading

• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–1292 . October 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . 6 . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . October 2005 . 16189514 . 10.1038/nature04209 . 4427026 . 2005Natur.437.1173R .
• Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA . 6 . Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport . Experimental Cell Research . 289 . 2 . 211–221 . October 2003 . 14499622 . 10.1016/S0014-4827(03)00261-1 .
• Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A . HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages . Nature Medicine . 9 . 2 . 191–197 . February 2003 . 12539042 . 10.1038/nm822 . 26145639 .
• Yu M, Tong JH, Mao M, Kan LX, Liu MM, Sun YW, Fu G, Jing YK, Yu L, Lepaslier D, Lanotte M, Wang ZY, Chen Z, Waxman S, Wang YX, Tan JZ, Chen SJ . 6 . Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulated genes . Proceedings of the National Academy of Sciences of the United States of America . 94 . 14 . 7406–7411 . July 1997 . 9207104 . 23834 . 10.1073/pnas.94.14.7406 . free . 1997PNAS...94.7406Y .

Notes and References

1. Fensterl V, Wetzel JL, Ramachandran S, Ogino T, Stohlman SA, Bergmann CC, Diamond MS, Virgin HW, Sen GC . 6 . Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis . PLOS Pathogens . 8 . 5 . e1002712 . 2012 . 22615570 . 3355090 . 10.1371/journal.ppat.1002712 . free .
2. de Veer MJ, Sim H, Whisstock JC, Devenish RJ, Ralph SJ . IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes . Genomics . 54 . 2 . 267–277 . December 1998 . 9828129 . 10.1006/geno.1998.5555 .
3. Zhu H, Cong JP, Shenk T . Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs . Proceedings of the National Academy of Sciences of the United States of America . 94 . 25 . 13985–13990 . December 1997 . 9391139 . 28419 . 10.1073/pnas.94.25.13985 . 1997PNAS...9413985Z . free .
4. Web site: Entrez Gene: IFIT3 interferon-induced protein with tetratricopeptide repeats 3.