IFI30 explained
Gamma-interferon-inducible lysosomal thiol reductase is an enzyme that, in humans, is encoded by the IFI30 gene.[1] [2] [3]
The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.
Further reading
- Csányi E . [Endre Kótai; 1914-1976] . Magyar traumatológia, orthopaedia és helyreállító sebészet . 20 . 1 . 1 . 1977 . 16170 .
- Sabin NM . Letters to the editors . The Journal of the Wisconsin Dental Association . 52 . 1 . 9 . 1977 . 1069150 .
- Phan UT, Arunachalam B, Cresswell P . Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action . J. Biol. Chem. . 275 . 34 . 25907–14 . 2000 . 10852914 . 10.1074/jbc.M003459200 . free .
- Phan UT, Maric M, Dick TP, Cresswell P . Multiple species express thiol oxidoreductases related to GILT . Immunogenetics . 53 . 4 . 342–6 . 2001 . 11491538 . 10.1007/s002510100323 . 848449 .
- Haque MA . Absence of γ-Interferon–inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes . J. Exp. Med. . 195 . 10 . 1267–77 . 2002 . 12021307 . 10.1084/jem.20011853 . 2193747 . vanc. Li P . Jackson SK . 3 . Zarour . HM . Hawes . JW . Phan . UT . Maric . M . Cresswell . P . Blum . JS .
- Phan UT, Lackman RL, Cresswell P . Role of the C-terminal propeptide in the activity and maturation of γ-interferon-inducible lysosomal thiol reductase (GILT) . Proc. Natl. Acad. Sci. U.S.A. . 99 . 19 . 12298–303 . 2002 . 12198183 . 10.1073/pnas.182430499 . 129439 . 2002PNAS...9912298P . free .
- Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
Notes and References
- Luster AD, Weinshank RL, Feinman R, Ravetch JV . Molecular and biochemical characterization of a novel gamma-interferon-inducible protein . J Biol Chem . 263 . 24 . 12036–43 . Sep 1988 . 10.1016/S0021-9258(18)37889-X . 3136170 . free .
- Arunachalam B, Phan UT, Geuze HJ, Cresswell P . Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT) . Proc Natl Acad Sci U S A . 97 . 2 . 745–50 . Mar 2000 . 10639150 . 15401 . 10.1073/pnas.97.2.745 . 2000PNAS...97..745A . free .
- Web site: Entrez Gene: IFI30 interferon, gamma-inducible protein 30.