IER3 explained

Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3 gene.^{[1] [2]}

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.^[3]

Further reading

• Wu MX . Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis. . Apoptosis . 8 . 1 . 11–8 . 2003 . 12510147 . 10.1023/A:1021688600370 . 20935065 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Schäfer H, Trauzold A, Siegel EG, etal . PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line. . Cancer Res. . 56 . 11 . 2641–8 . 1996 . 8653710 .
• Pietzsch A, Büchler C, Aslanidis C, Schmitz G . Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine. . Biochem. Biophys. Res. Commun. . 235 . 1 . 4–9 . 1997 . 9196025 . 10.1006/bbrc.1997.6715 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Pietzsch A, Büchler C, Schmitz G . Genomic organization, promoter cloning, and chromosomal localization of the Dif-2 gene. . Biochem. Biophys. Res. Commun. . 245 . 3 . 651–7 . 1998 . 9588170 . 10.1006/bbrc.1998.8500 .
• Schäfer H, Diebel J, Arlt A, etal . The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB. . FEBS Lett. . 436 . 2 . 139–43 . 1998 . 9781666 . 10.1016/S0014-5793(98)01109-0 . 28479652 .
• Kobayashi T, Pittelkow MR, Warner GM, etal . Regulation of a novel immediate early response gene, IEX-1, in keratinocytes by 1alpha,25-dihydroxyvitamin D3. . Biochem. Biophys. Res. Commun. . 251 . 3 . 868–73 . 1998 . 9791001 . 10.1006/bbrc.1998.9556 .
• Kumar R, Kobayashi T, Warner GM, etal . A novel immediate early response gene, IEX-1, is induced by ultraviolet radiation in human keratinocytes. . Biochem. Biophys. Res. Commun. . 253 . 2 . 336–41 . 1999 . 9878538 . 10.1006/bbrc.1998.9692 .
• Schäfer H, Arlt A, Trauzold A, etal . The putative apoptosis inhibitor IEX-1L is a mutant nonspliced variant of p22(PRG1/IEX-1) and is not expressed in vivo. . Biochem. Biophys. Res. Commun. . 262 . 1 . 139–45 . 1999 . 10448082 . 10.1006/bbrc.1999.1131 .
• Feldmann KA, Pittelkow MR, Roche PC, etal . Expression of an immediate early gene, IEX-1, in human tissues. . Histochem. Cell Biol. . 115 . 6 . 489–97 . 2001 . 11455449 . 10.1007/s004180100284 . 24380294 .
• Zhang Y, Schlossman SF, Edwards RA, etal . Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 2 . 878–83 . 2002 . 11782530 . 10.1073/pnas.022326699 . 117399 . 2002PNAS...99..878Z . free .
• Im HJ, Pittelkow MR, Kumar R . Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1. . J. Biol. Chem. . 277 . 17 . 14612–21 . 2002 . 11844788 . 2895739 . 10.1074/jbc.M109414200 . free .
• Ohki R, Yamamoto K, Mano H, etal . Identification of mechanically induced genes in human monocytic cells by DNA microarrays. . J. Hypertens. . 20 . 4 . 685–91 . 2002 . 11910304 . 10.1097/00004872-200204000-00026 . 34968458 .
• Im HJ, Craig TA, Pittelkow MR, Kumar R . Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1alpha,25-dihydroxyvitamin D(3)-associated IEX-1 gene repression. . Oncogene . 21 . 23 . 3706–14 . 2002 . 12032839 . 10.1038/sj.onc.1205450 . 38132204 .
• Garcia J, Ye Y, Arranz V, etal . IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. . EMBO J. . 21 . 19 . 5151–63 . 2002 . 12356731 . 10.1093/emboj/cdf488 . 129026 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .

Notes and References

1. Kondratyev AD, Chung KN, Jung MO . Identification and characterization of a radiation-inducible glycosylated human early-response gene . Cancer Res . 56 . 7 . 1498–502 . May 1996 . 8603392 .
2. Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF . IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival . Science . 281 . 5379 . 998–1001 . Aug 1998 . 9703517 . 10.1126/science.281.5379.998 . 1998Sci...281..998W .
3. Web site: Entrez Gene: IER3 immediate early response 3.