ICK (gene) explained

Serine/threonine-protein kinase, Intestinal cell kinase or ICK^[1] is an enzyme that in humans is encoded by the ICK gene.^{[2] [3]}

Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.

Further reading

• Nagase T, Ishikawa K, Suyama M, etal . Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. . DNA Res. . 6 . 1 . 63–70 . 1999 . 10231032 . 10.1093/dnares/6.1.63 . free .
• Togawa K, Yan YX, Inomoto T, etal . Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases. . J. Cell. Physiol. . 183 . 1 . 129–39 . 2000 . 10699974 . 10.1002/(SICI)1097-4652(200004)183:1<129::AID-JCP15>3.0.CO;2-S . 41279862 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
• Colland F, Jacq X, Trouplin V, etal . Functional proteomics mapping of a human signaling pathway. . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Fu Z, Schroeder MJ, Shabanowitz J, etal . Activation of a nuclear Cdc2-related kinase within a mitogen-activated protein kinase-like TDY motif by autophosphorylation and cyclin-dependent protein kinase-activating kinase. . Mol. Cell. Biol. . 25 . 14 . 6047–64 . 2005 . 15988018 . 10.1128/MCB.25.14.6047-6064.2005 . 1168834 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .

Notes and References

1. Web site: ICK intestinal cell kinase [Homo sapiens (human)] - Gene - NCBI]. www.ncbi.nlm.nih.gov. 2018-01-26.
2. Yang T, Jiang Y, Chen J . The identification and subcellular localization of human MRK . Biomol Eng . 19 . 1 . 1–4 . Jul 2002 . 12103360 . 10.1016/S1389-0344(02)00002-3 .
3. Web site: Entrez Gene: ICK intestinal cell (MAK-like) kinase.