ICI-204,448 explained

ICI-204,448 is a drug which acts as a potent and peripherally selective κ-opioid agonist, with possible uses in the treatment of heart attack as well as anti-itching effects.[1] [2] It is used in research to distinguish centrally from peripherally mediated kappa opioid receptor effects.[3] [4]

Notes and References

  1. Peart JN, Gross ER, Gross GJ . Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction . Journal of Cardiovascular Pharmacology . 43 . 3 . 410–5 . March 2004 . 15076225 . 10.1097/00005344-200403000-00012. 36736279 . free .
  2. Inan S, Cowan A . Kappa opioid agonists suppress chloroquine-induced scratching in mice . European Journal of Pharmacology . 502 . 3 . 233–7 . October 2004 . 15476749 . 10.1016/j.ejphar.2004.09.010 .
  3. Schindler CW, Graczyk Z, Gilman JP, Negus SS, Bergman J, Mello NK, Goldberg SR . Effects of kappa opioid agonists alone and in combination with cocaine on heart rate and blood pressure in conscious squirrel monkeys . European Journal of Pharmacology . 576 . 1–3 . 107–13 . December 2007 . 17707792 . 10.1016/j.ejphar.2007.07.053 . 2080578.
  4. Shannon HE, Eberle EL, Mitch CH, McKinzie DL, Statnick MA . Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats . Neuropharmacology . 53 . 8 . 930–41 . December 2007 . 17959202 . 10.1016/j.neuropharm.2007.09.002 . 38651220 .

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