ICAM2 explained

Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human gene, and the protein resulting from it.

Protein structure

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2–9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein.

Protein functions

ICAM-2 molecules regulate spermatid adhesion on Sertoli cell on the apical side of the blood-testis barrier (towards the lumen), thus playing a major role in spermatogenesis.^[1]

This protein may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.^[2]

Interactions

ICAM2 has been shown to interact with EZR.^[3] It has also been shown to bind to P9 (Uniprot: B2UM07), a secreted protein from Akkermansia muciniphila.^[4]

See also

• Cluster of differentiation

Further reading

• Simmons DL . The role of ICAM expression in immunity and disease . Cancer Surveys . 24 . 141–55 . 1995 . 7553659 .
• Hayflick JS, Kilgannon P, Gallatin WM . The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions . Immunologic Research . 17 . 3 . 313–27 . 1998 . 9638475 . 10.1007/BF02786454 . 19901365 .
• Lalor PF, Shields P, Grant A, Adams DH . Recruitment of lymphocytes to the human liver . Immunology and Cell Biology . 80 . 1 . 52–64 . February 2002 . 11869363 . 10.1046/j.1440-1711.2002.01062.x . 19892941 .
• Yonekawa K, Harlan JM . Targeting leukocyte integrins in human diseases . Journal of Leukocyte Biology . 77 . 2 . 129–40 . February 2005 . 15548573 . 10.1189/jlb.0804460 . 44606865 . free .
• de Fougerolles AR, Stacker SA, Schwarting R, Springer TA . Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1 . The Journal of Experimental Medicine . 174 . 1 . 253–67 . July 1991 . 1676048 . 2118873 . 10.1084/jem.174.1.253 .
• Sansom D, Borrow J, Solomon E, Trowsdale J . The human ICAM2 gene maps to 17q23-25 . Genomics . 11 . 2 . 462–4 . October 1991 . 1769660 . 10.1016/0888-7543(91)90157-A .
• Staunton DE, Dustin ML, Springer TA . Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1 . Nature . 339 . 6219 . 61–4 . May 1989 . 2497351 . 10.1038/339061a0 . 1989Natur.339...61S . 4326657 .
• Bujía J, Holly A, Kim C, Scanady N, Kastenbauer E . Expression of human intercellular adhesion molecules in middle ear cholesteatoma . American Journal of Otolaryngology . 15 . 4 . 271–5 . 1994 . 7526720 . 10.1016/0196-0709(94)90094-9 .
• de Fougerolles AR, Qin X, Springer TA . Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses . The Journal of Experimental Medicine . 179 . 2 . 619–29 . February 1994 . 7905020 . 2191386 . 10.1084/jem.179.2.619 .
• Butini L, De Fougerolles AR, Vaccarezza M, Graziosi C, Cohen DI, Montroni M, Springer TA, Pantaleo G, Fauci AS . Intercellular adhesion molecules (ICAM)-1 ICAM-2 and ICAM-3 function as counter-receptors for lymphocyte function-associated molecule 1 in human immunodeficiency virus-mediated syncytia formation . European Journal of Immunology . 24 . 9 . 2191–5 . September 1994 . 7916296 . 10.1002/eji.1830240939 . 24872330 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Hirao M, Sato N, Kondo T, Yonemura S, Monden M, Sasaki T, Takai Y, Tsukita S, Tsukita S . Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway . The Journal of Cell Biology . 135 . 1 . 37–51 . October 1996 . 8858161 . 2121020 . 10.1083/jcb.135.1.37 .
• Bernstein CN, Sargent M, Gallatin WM, Wilkins J . Beta 2-integrin/intercellular adhesion molecule (ICAM) expression in the normal human intestine . Clinical and Experimental Immunology . 106 . 1 . 160–9 . October 1996 . 8870715 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . September 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Casasnovas JM, Springer TA, Liu JH, Harrison SC, Wang JH . Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface . Nature . 387 . 6630 . 312–5 . May 1997 . 9153399 . 10.1038/387312a0 . 1997Natur.387..312C . 4276760 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Sainio M, Zhao F, Heiska L, Turunen O, den Bakker M, Zwarthoff E, Lutchman M, Rouleau GA, Jääskeläinen J, Vaheri A, Carpén O . Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton . Journal of Cell Science . 110 . 18. 2249–60 . September 1997 . 9378774 . 110 . 10.1242/jcs.110.18.2249 .
• Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S . Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2 . The Journal of Cell Biology . 140 . 4 . 885–95 . February 1998 . 9472040 . 2141743 . 10.1083/jcb.140.4.885 .
• Bernstein CN, Sargent M, Gallatin WM . Beta2 integrin/ICAM expression in Crohn's disease . Clinical Immunology and Immunopathology . 86 . 2 . 147–60 . February 1998 . 9473377 . 10.1006/clin.1997.4462 .

External links

• • PDBe-KB provides an overview of all the structure information available in the PDB for Human Intercellular adhesion molecule 2 (ICAM2)

Notes and References

1. Xiao X, Mruk DD, Cheng CY . Intercellular adhesion molecules (ICAMs) and spermatogenesis . Human Reproduction Update . 19 . 2 . 167–86 . 2013 . 23287428 . 3576004 . 10.1093/humupd/dms049 .
2. Web site: Entrez Gene: ICAM2 intercellular adhesion molecule 2.
3. Heiska L, Alfthan K, Grönholm M, Vilja P, Vaheri A, Carpén O . Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4, 5-bisphosphate . The Journal of Biological Chemistry . 273 . 34 . 21893–900 . August 1998 . 9705328 . 10.1074/jbc.273.34.21893 . free .
4. Yoon HS, Cho CH, Yun MS, Jang SJ, You HJ, Kim JH, Han D, Cha KH, Moon SH, Lee K, Kim YJ, Lee SJ, Nam TW, Ko G . Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice . Nature Microbiology . 6 . 5 . 563–573 . May 2021 . 33820962 . 10.1038/s41564-021-00880-5 . 233037565 .