IC-26 explained

IC-26^[1] (WIN 1161-3, Methiodone)^[2] is an analogue of the opioid analgesic methadone, where the carbonyl group has been replaced by the bioisosteric sulfone group.

Human and animal studies suggest that IC-26 is around the same potency as methadone,^{[3] [4]} although other studies have found its activity to be inconsistent between different patients, with consistent opioid activity only being seen at a dose several times that of methadone. IC-26 was assessed for its abuse potential, but despite being found to have similar potential to morphine for development of dependence^[5] it was never placed under international control as an illegal drug.

See also

• Dextromoramide
• Dipipanone
• MT-45
• Phenadoxone

Notes and References

1. Tullar BF, Wetterau W, Archer S . The Resolution of Ethyl 1,1-Diphenyl-3-dimethylaminobutyl Sulfone . Journal of the American Chemical Society . November 1948 . 70 . 11 . 3959–3960 . 10.1021/ja01191a532. 18207952 .
2. US . patent . 2618640 . 1952-11-18 . Certain amino hydrocarbon sulfones and process of preparation . Archer S, Suter CM, Tullar BF . Sterling Drug .
3. Book: Lednicer, D. . Central Analgetics . 1982 . 194 . Wiley . 0-471-08314-3 .
4. Book: Janssen PA . XVIII Sulphones . Synthetic Analgesics . 1 . Diphenylpropylamines . Pergamon Press . 1960 . 160–163 . 59-13814 . https://www.scribd.com/doc/16407915/Synthetic-Analgesics-Vol-1-Diphenylpropylamines-Paul-Janssen-1960#page=166 .
5. Wolbach AB, Fraser HF . Addiction Liability of I-C-26 . Bulletin on Narcotics . UNODC . 1963 . 1963 . 1 . 25–28 .