Iodobenzamide Explained

Iodobenzamide (IBZM or iolopride) is a pharmaceutical drug used for diagnostic purposes. It is a dopamine antagonist and it can be used by nuclear medicine physicians as a radioactive tracer for SPECT where the radioactive isotope is iodine-123 or iodine-125.[1] [2] The main purpose of a brain study with IBZM is the differentiation of Parkinson's disease from other neurodegenerative diseases such as Lewy Body dementia and multiple system atrophy.

Notes and References

  1. Kung, H. F. . Guo, Y. Z. . Billings, J. . Xu, X. . Mach, R. H. . Blau, M. . Ackerhalt, R. E. . Preparation and biodistribution of [125I]IBZM: a potential CNS D-2 dopamine receptor imaging agent . Nuclear Medicine and Biology . 1988 . 15 . 2 . 195–201 . 2966782 . 10.1016/0883-2897(88)90088-8.
  2. Kung, Hank, F. . In vivo SPECT imaging of CNS D-2 dopamine receptors: initial studies with iodine-123-IBZM in humans . Journal of Nuclear Medicine . 1990 . 31 . 5 . 573–579 . Alavi . Chang . Kung . Keyes . Velchik . Billings . Pan . Noto . 2140408.

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