| I. Clinton Kline | |
| Image Name: | Isaac Clinton Kline (Pennsylvania Congressman).jpg |
| Caption: | Harris & Ewing Collection, Library of Congress |
| State: | Pennsylvania |
| District: | 16th |
| Term Start: | March 4, 1921 |
| Term End: | March 3, 1923 |
| Preceded: | John V. Lesher |
| Succeeded: | Edgar R. Kiess |
| Birth Date: | 18 August 1858 |
| Birth Place: | Mount Pleasant, Pennsylvania, U.S. |
| Death Place: | DeLand, Florida, U.S. |
| Party: | Republican |
| Alma Mater: | State Normal School (Bloomsburg) Bucknell Academy Lafayette College |
Isaac Clinton Kline (August 18, 1858 – December 2, 1947) was a Republican member of the U.S. House of Representatives from Pennsylvania.
He was born in Mount Pleasant, Pennsylvania. He attended the State Normal School in Bloomsburg, Pennsylvania, and Bucknell Academy in Lewisburg, Pennsylvania. He graduated from Lafayette College in Easton, Pennsylvania, in 1893. He taught school five years before entering college. He studied law, was admitted to the bar in 1894 and commenced practice in Sunbury, Pennsylvania.
Kline was an unsuccessful candidate for election in 1912, but was elected as a Republican to the Sixty-seventh Congress. He was an unsuccessful candidate for reelection in 1922. He resumed the practice of his profession in Sunbury, and died in DeLand, Florida. Interment in Pomfret Manor Cemetery, in Sunbury.