In human neuroanatomy, the hypothalamotegmental tract is a pathway from the hypothalamus to the reticular formation.[1] Axons from the posterior hypothalamus descend through the mesencephalic and pontine reticular formations. They connect with reticular neurons important in visceral and autonomic activity. The tract is a continuation of the medial forebrain bundle in the lateral portion of the tegmentum. It is not visible without special stains.