Hydroxypyruvate reductase explained

hydroxypyruvate reductase
Ec Number:	1.1.1.81
Cas Number:	9059-44-3
Go Code:	0016618

In enzymology, a hydroxypyruvate reductase is an enzyme that catalyzes the chemical reaction

D-glycerate + NAD(P)+

\rightleftharpoons hydroxypyruvate + NAD(P)H + H⁺

The 3 substrates of this enzyme are D-glycerate, NAD⁺, and NADP⁺, whereas its 4 products are hydroxypyruvate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-glycerate:NADP⁺ 2-oxidoreductase. Other names in common use include beta-hydroxypyruvate reductase, NADH:hydroxypyruvate reductase, and D-glycerate dehydrogenase. This enzyme participates in glycine, serine and threonine metabolism and glyoxylate and dicarboxylate metabolism.

See also

• Oxidoreductases
• Enzymes
• Enzyme Commission number (EC number)

References

• Kleczkowski LA . Edwards GE . 1989 . Identification of hydroxypyruvate and glyoxylate reductases in maize leaves . Plant Physiol. . 91 . 1 . 278 - 286 . 10.1104/pp.91.1.278 . 1061987 . 16667010.
• Kleczkowski LA, Randall DD . 1988 . Purification and characterization of a novel NADPH(NADH)-dependent hydroxypyruvate reductase from spinach leaves. Comparison of immunological properties of leaf hydroxypyruvate reductases . Biochem. J. . 250 . 145 - 52 . 3281657 . 1 . 10.1042/bj2500145 . 1148826 .
• Kohn LD, Jakoby WB . 1968 . Tartaric acid metabolism. VII. Crystalline hydroxypyruvate reductase (D-glycerate dehydrogenase) . J. Biol. Chem. . 243 . 2494 - 9 . 4385077 . 10 .