Hydroxyphenylpyruvate reductase explained

hydroxyphenylpyruvate reductase
Ec Number:	1.1.1.237
Cas Number:	117590-77-9
Go Code:	0047995

In enzymology, a hydroxyphenylpyruvate reductase is an enzyme that catalyzes the chemical reaction

3-(4-hydroxyphenyl)lactate + NAD⁺

\rightleftharpoons 3-(4-hydroxyphenyl)pyruvate + NADH + H⁺

Thus, the two substrates of this enzyme are 3-(4-hydroxyphenyl)lactate and NAD⁺, whereas its 3 products are 3-(4-hydroxyphenyl)pyruvate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 4-hydroxyphenyllactate:NAD⁺ oxidoreductase. This enzyme is also called HPRP. This enzyme participates in tyrosine metabolism and phenylalanine metabolism.

References

• Petersen M, Alfermann AW . 1988 . Two new enzymes of rosmarinic acid biosynthesis from cell cultures of Coleus blumei: hydroxyphenylpyruvate reductase and rosmarinic acid synthase . Z. Naturforsch. C: Biosci. . 43 . 501 - 504 .