Hydroxetamine Explained

Hydroxetamine (3'-hydroxy-2-oxo-PCE, O-desmethylmethoxetamine, HXE) is a recreational designer drug from the arylcyclohexylamine family, with dissociative effects. It is known as an active metabolite of the dissociative designer drug methoxetamine,^{[1] [2]} but has also been sold in its own right since late 2019.^[3]

See also

• 3-HO-PCP
• 4-Keto-PCP
• Desmetramadol
• Deoxymethoxetamine
• Fluorexetamine

Notes and References

1. Menzies EL, Hudson SC, Dargan PI, Parkin MC, Wood DM, Kicman AT . Characterizing metabolites and potential metabolic pathways for the novel psychoactive substance methoxetamine . Drug Testing and Analysis . 6 . 6 . 506–15 . June 2014 . 24574323 . 10.1002/dta.1541 .
2. Horsley RR, Lhotkova E, Hajkova K, Jurasek B, Kuchar M, Palenicek T . Detailed pharmacological evaluation of methoxetamine (MXE), a novel psychoactive ketamine analogue-Behavioural, pharmacokinetic and metabolic studies in the Wistar rat . Brain Research Bulletin . 126 . Pt 1 . 102–110 . September 2016 . 27155360 . 10.1016/j.brainresbull.2016.05.002 . 3955788 .
3. https://ndews.org/?wysija-page=1&controller=email&action=view&email_id=157&wysijap=subscriptions Alert from NDEWS Web Monitoring Team: Increases in Reddit discussions of HXE in February-May of 2021. National Drug Early Warning System, Issue 39, 11 June 2021. University of Florida, funded by the National Institute on Drug Abuse