Hydrangenol Explained

Hydrangenol is a dihydroisocoumarin. It can be found in Hydrangea macrophylla, as well as its 8-O-glucoside.^[1] (−)-Hydrangenol 4′-O-glucoside^[2] and (+)-hydrangenol 4′-O-glucoside^[3] can be found in Hydrangeae Dulcis Folium, the processed leaves of H. macrophylla var. thunbergii.

Notes and References

1. Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols A and F from Hydrangea macrophylla Seringe var. thunbergii Makino on passive cutaneous anaphylaxis reaction in rats. Biological & Pharmaceutical Bulletin. 1999. 22. 8. 870–872. . 10.1248/bpb.22.870. Matsuda. Hisashi. Simoda. Hiroshi. Yamahara. Johji. Yoshikawa. Masayuki. 10480329. free.
2. 1363465. 1992. Yoshikawa. M. Uchida. E. Chatani. N. Kobayashi. H. Naitoh. Y. Okuno. Y. Matsuda. H. Yamahara. J. Murakami. N. Thunberginols C, D, and E, new antiallergic and antimicrobial dihydroisocoumarins, and thunberginol G 3′-O-glucoside and (−)-hydrangenol 4′-O-glucoside, new dihydroisocoumarin glycosides, from Hydrangeae Dulcis Folium. 40. 12. 3352–3354. Chemical & Pharmaceutical Bulletin. 10.1248/cpb.40.3352. free.
3. 8795265. . 1996. Yoshikawa. M. Matsuda. H. Shimoda. H. Shimada. H. Harada. E. Naitoh. Y. Miki. A. Yamahara. J. Murakami. N. Development of bioactive functions in Hydrangeae Dulcis Folium. V. On the antiallergic and antimicrobial principles of Hydrangeae Dulcis Folium. (2). Thunberginols C, D, and E, thunberginol G 3′-O-glucoside, (−)-hydrangenol 4′-O-glucoside, and (+)-hydrangenol 4′-O-glucoside. 44. 8. 1440–1447. Chemical & Pharmaceutical Bulletin. 10.1248/cpb.44.1440 . free.