HycI peptidase explained

HycI peptidase
Ec Number:3.4.23.51

HycI peptidase (HycI, HycE processing protein) is an enzyme.[1] [2] This enzyme catalyses the following chemical reaction

This enzyme specifically removes a 32-amino acid peptide from the C-terminus of the precursor of the large subunit of hydrogenase 3 in Escherichia coli by cleavage at the C-terminal side of Arg537.

This enzyme belongs to the peptidase family A31.

Notes and References

  1. Theodoratou E, Paschos A, Magalon A, Fritsche E, Huber R, Böck A . Nickel serves as a substrate recognition motif for the endopeptidase involved in hydrogenase maturation . European Journal of Biochemistry . 267 . 7 . 1995–9 . April 2000 . 10727938 . 10.1046/j.1432-1327.2000.01202.x .
  2. Yang F, Hu W, Xu H, Li C, Xia B, Jin C . Solution structure and backbone dynamics of an endopeptidase HycI from Escherichia coli: implications for mechanism of the [NiFe] hydrogenase maturation . The Journal of Biological Chemistry . 282 . 6 . 3856–63 . February 2007 . 17150961 . 10.1074/jbc.m609263200 . free .

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