Hurd–Mori 1,2,3-thiadiazole synthesis explained

The Hurd–Mori 1,2,3-thiadiazole synthesis is a name reaction in organic chemistry that allows for the generation of 1,2,3-thiadiazoles through the reaction of N-acylated or tosyl hydrazone derivatives with thionyl chloride.^{[1] [2] [3] [4]}

Notes and References

1. Hurd . Charles D. . Mori . Raymond I. . On Acylhydrazones and 1,2,3-Thiadiazoles . Journal of the American Chemical Society . 1995-10-01 . 77 . 20 . 5359–5364 . 10.1021/ja01625a047.
2. Turner . Martin . Linder . Thomas . Schnürch . Michael . Mihovilovic . Marko D. . Stanetty . Peter . Investigation of the regioselectivity of the Hurd–Mori reaction for the formation of bicyclic 1,2,3-thiadiazoles . Tetrahedron . 2010-07-17 . 66 . 29 . 5472–5478 . 10.1016/j.tet.2010.05.017.
3. Morzherin . Yuriy Yur`evich . Glukhareva . Tatiana V. . Bakulev . Vasiliy A. . Rearrangements and Transformations of 1,2,3-Thiadiazoles in Organic Synthesis. (Review) . Chemistry of Heterocyclic Compounds . June 2003 . 39 . 6 . 679–706 . 10.1023/A:1025689208261. 97346885 .
4. Thuc . Dinh Ngoc . Synthesis and characterization of some new 1,2,3-thiadiazole and 1,2,3-selenadiazole triterpene derivatives from allobetulone and 2-oxoallobetulin . Synthetic Communications . 2020 . 50 . 11 . 1665–1671 . 10.1080/00397911.2020.1750655. 219092397 .