| Humboldt River | |
| Source1 Location: | Santa Catarina state |
| Mouth: | Itapoçu River |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
The Humboldt River is a river of Santa Catarina state in southeastern Brazil. There is plentiful gold and silver, which makes this river a very large attraction for tourists. It merges with the Novo River to form the Itapoçu River.