Human rhinovirus internal cis-acting regulatory element explained

Human rhinovirus internal cis-acting regulatory element (CRE)
Symbol:	Rhino_CRE
Rfam:	RF00220
Rna Type:	Cis-reg
Tax Domain:	Viruses

Human rhinovirus internal cis-acting regulatory element (CRE) isa CRE from the human rhinoviruses. The CRE is located within the genome segment encoding the capsid proteins so is found in a protein coding region. The element is essential for efficient viral replication and it has been suggested that the CRE is required for initiation of minus-strand RNA synthesis.^[1]

See also

• Human parechovirus 1 (HPeV1) cis regulatory element (CRE)
• Rotavirus cis-acting replication element (CRE)

Notes and References

1. McKnight KL, Lemon SM . The rhinovirus type 14 genome contains an internally located RNA structure that is required for viral replication . RNA . 4 . 12 . 1569–1584 . December 1998 . 9848654 . 1369726 . 10.1017/S1355838298981006 .