Human endogenous retrovirus K endopeptidase explained

Human endogenous retrovirus K endopeptidase
Ec Number:3.4.23.50

Human endogenous retrovirus K endopeptidase (human endogenous retrovirus K10 endopeptidase, endogenous retrovirus HERV-K10 putative protease, human endogenous retrovirus K retropepsin, HERV K10 endopeptidase, HERV K10 retropepsin, HERV-K PR, HERV-K protease, HERV-K113 protease, human endogenous retrovirus K113 protease, human retrovirus K10 retropepsin) is an enzyme derived from an endogenous retrovirus.[1] This enzyme catalyses the following chemical reaction:

Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-PIVQ- cleavage site.

This enzyme belongs to the peptidase family A2 (retropepsins).

Notes and References

  1. Towler EM, Gulnik SV, Bhat TN, Xie D, Gustschina E, Sumpter TR, Robertson N, Jones C, Sauter M, Mueller-Lantzsch N, Debouck C, Erickson JW . Functional characterization of the protease of human endogenous retrovirus, K10: can it complement HIV-1 protease? . Biochemistry . 37 . 49 . 17137–44 . December 1998 . 9860826 . 10.1021/bi9818927 .