Human betaherpesvirus 6A explained
Human betaherpesvirus 6A (HHV-6A) is a species of virus in the genus Roseolovirus, subfamily Betaherpesvirinae, family Herpesviridae, and order Herpesvirales.[1]
HHV-6A and infertility
- A 2016 study showed that 43% of women with unexplained infertility tested positive for HHV-6A while 0% of women in the fertile control group tested positive. HHV-6A was found present in endrometrial epithelial cells from women with unexplained infertility. [2]
- A 2018 study reports the prevalence of HHV-6A in endometrial biopsies among women experiencing recurrent implantation failure after IVF/ET compared to control groups.[3]
- A 2019 study confirmed the presence of HHV-6A infection in 40% of idiopathic infertile women. Identifying the effect of HHV-6A infection on endometrial immune status opens up a new perspectives on fertility care. Its possible to choose antiviral therapies and non-hormonal approaches for women with unexplained infertility characterized by HHV-6A to increase their pregnancy rate.[4]
Taxonomy
In 1992 the two variants were recognised within Human herpesvirus 6 on the basis of differing restriction endonuclease cleavages, monoclonal antibody reactions,[5] and growth patterns.[6] In 2012 these two variants were officially recognised as distinct species by the International Committee on Taxonomy of Viruses and named Human betaherpesvirus 6A and Human betaherpesvirus 6B.[7] Despite now being recognised as paraphyletic, the name Human herpesvirus 6 still sees usage in clinical contexts.
Pathology
See also: Human herpesvirus 6. Human betaherpesvirus 6A affects humans and includes several adult-derived strains. Its disease spectrum is not well defined, although it is thought by some to be more neurovirulent than Human betaherpesvirus 6B.[8] [9]
Notes and References
- Web site: ICTV Master Species List 2018b.v2. https://web.archive.org/web/20190330100806/https://talk.ictvonline.org/files/master-species-lists/m/msl/8266. dead. March 30, 2019. International Committee on Taxonomy of Viruses (ICTV). 19 June 2019.
- Marci R, Gentili V, Bortolotti D, Lo Monte G, Caselli E, Bolzani S, Rotola A, Di Luca D, Rizzo R . 6 . Presence of HHV-6A in Endometrial Epithelial Cells from Women with Primary Unexplained Infertility . PLOS ONE . 11 . 7 . e0158304 . 2016-07-01 . 27367597 . 4930213 . 10.1371/journal.pone.0158304 . free . 2016PLoSO..1158304M .
- Coulam CB, Bilal M, Salazar Garcia MD, Katukurundage D, Elazzamy H, Fernandez EF, Kwak-Kim J, Beaman K, Dambaeva SV . 6 . Prevalence of HHV-6 in endometrium from women with recurrent implantation failure . American Journal of Reproductive Immunology . 80 . 1 . e12862 . July 2018 . 29667291 . 10.1111/aji.12862 . 4944870 .
- Bortolotti D, Gentili V, Rotola A, Cultrera R, Marci R, Di Luca D, Rizzo R . HHV-6A infection of endometrial epithelial cells affects immune profile and trophoblast invasion . American Journal of Reproductive Immunology . 82 . 4 . e13174 . October 2019 . 31338899 . 10.1111/aji.13174 . 198193327 . 11392/2406194 . free .
- Kawabata A, Oyaizu H, Maeki T, Tang H, Yamanishi K, Mori Y . Analysis of a neutralizing antibody for human herpesvirus 6B reveals a role for glycoprotein Q1 in viral entry . Journal of Virology . 85 . 24 . 12962–12971 . December 2011 . 21957287 . 3233151 . 10.1128/JVI.05622-11 .
- Braun DK, Dominguez G, Pellett PE . Human herpesvirus 6 . Clinical Microbiology Reviews . 10 . 3 . 521–567 . July 1997 . 9227865 . 172933 . 10.1128/CMR.10.3.521 .
- Adams MJ, Carstens EB . Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2012) . Archives of Virology . 157 . 7 . 1411–1422 . July 2012 . 22481600 . 7086667 . 10.1007/s00705-012-1299-6 . free .
- Kofman A, Marcinkiewicz L, Dupart E, Lyshchev A, Martynov B, Ryndin A, Kotelevskaya E, Brown J, Schiff D, Abounader R . 6 . The roles of viruses in brain tumor initiation and oncomodulation . Journal of Neuro-Oncology . 105 . 3 . 451–466 . December 2011 . 21720806 . 3278219 . 10.1007/s11060-011-0658-6 .
- Arbuckle JH, Medveczky MM, Luka J, Hadley SH, Luegmayr A, Ablashi D, Lund TC, Tolar J, De Meirleir K, Montoya JG, Komaroff AL, Ambros PF, Medveczky PG . 6 . The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro . Proceedings of the National Academy of Sciences of the United States of America . 107 . 12 . 5563–5568 . March 2010 . 20212114 . 2851814 . 10.1073/pnas.0913586107 . free . 2010PNAS..107.5563A .