Human betaherpesvirus 6A explained

Human betaherpesvirus 6A (HHV-6A) is a species of virus in the genus Roseolovirus, subfamily Betaherpesvirinae, family Herpesviridae, and order Herpesvirales.[1]

HHV-6A and infertility

Taxonomy

In 1992 the two variants were recognised within Human herpesvirus 6 on the basis of differing restriction endonuclease cleavages, monoclonal antibody reactions,[5] and growth patterns.[6] In 2012 these two variants were officially recognised as distinct species by the International Committee on Taxonomy of Viruses and named Human betaherpesvirus 6A and Human betaherpesvirus 6B.[7] Despite now being recognised as paraphyletic, the name Human herpesvirus 6 still sees usage in clinical contexts.

Pathology

See also: Human herpesvirus 6. Human betaherpesvirus 6A affects humans and includes several adult-derived strains. Its disease spectrum is not well defined, although it is thought by some to be more neurovirulent than Human betaherpesvirus 6B.[8] [9]

Notes and References

  1. Web site: ICTV Master Species List 2018b.v2. https://web.archive.org/web/20190330100806/https://talk.ictvonline.org/files/master-species-lists/m/msl/8266. dead. March 30, 2019. International Committee on Taxonomy of Viruses (ICTV). 19 June 2019.
  2. Marci R, Gentili V, Bortolotti D, Lo Monte G, Caselli E, Bolzani S, Rotola A, Di Luca D, Rizzo R . 6 . Presence of HHV-6A in Endometrial Epithelial Cells from Women with Primary Unexplained Infertility . PLOS ONE . 11 . 7 . e0158304 . 2016-07-01 . 27367597 . 4930213 . 10.1371/journal.pone.0158304 . free . 2016PLoSO..1158304M .
  3. Coulam CB, Bilal M, Salazar Garcia MD, Katukurundage D, Elazzamy H, Fernandez EF, Kwak-Kim J, Beaman K, Dambaeva SV . 6 . Prevalence of HHV-6 in endometrium from women with recurrent implantation failure . American Journal of Reproductive Immunology . 80 . 1 . e12862 . July 2018 . 29667291 . 10.1111/aji.12862 . 4944870 .
  4. Bortolotti D, Gentili V, Rotola A, Cultrera R, Marci R, Di Luca D, Rizzo R . HHV-6A infection of endometrial epithelial cells affects immune profile and trophoblast invasion . American Journal of Reproductive Immunology . 82 . 4 . e13174 . October 2019 . 31338899 . 10.1111/aji.13174 . 198193327 . 11392/2406194 . free .
  5. Kawabata A, Oyaizu H, Maeki T, Tang H, Yamanishi K, Mori Y . Analysis of a neutralizing antibody for human herpesvirus 6B reveals a role for glycoprotein Q1 in viral entry . Journal of Virology . 85 . 24 . 12962–12971 . December 2011 . 21957287 . 3233151 . 10.1128/JVI.05622-11 .
  6. Braun DK, Dominguez G, Pellett PE . Human herpesvirus 6 . Clinical Microbiology Reviews . 10 . 3 . 521–567 . July 1997 . 9227865 . 172933 . 10.1128/CMR.10.3.521 .
  7. Adams MJ, Carstens EB . Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2012) . Archives of Virology . 157 . 7 . 1411–1422 . July 2012 . 22481600 . 7086667 . 10.1007/s00705-012-1299-6 . free .
  8. Kofman A, Marcinkiewicz L, Dupart E, Lyshchev A, Martynov B, Ryndin A, Kotelevskaya E, Brown J, Schiff D, Abounader R . 6 . The roles of viruses in brain tumor initiation and oncomodulation . Journal of Neuro-Oncology . 105 . 3 . 451–466 . December 2011 . 21720806 . 3278219 . 10.1007/s11060-011-0658-6 .
  9. Arbuckle JH, Medveczky MM, Luka J, Hadley SH, Luegmayr A, Ablashi D, Lund TC, Tolar J, De Meirleir K, Montoya JG, Komaroff AL, Ambros PF, Medveczky PG . 6 . The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro . Proceedings of the National Academy of Sciences of the United States of America . 107 . 12 . 5563–5568 . March 2010 . 20212114 . 2851814 . 10.1073/pnas.0913586107 . free . 2010PNAS..107.5563A .

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