| Hugo Santacruz | |
| Fullname: | Hugo Sebastian Santacruz Villalba |
| Birth Date: | 1989 2, df=yes |
| Birth Place: | Yasy Cañy, Paraguay |
| Height: | 1.80m |
| Position: | Attacker |
| Currentclub: | Rubio Ñu |
| Clubnumber: | 9 |
| Years1: | 2010–2016 |
| Clubs1: | Libertad |
| Caps1: | 12 |
| Goals1: | 2 |
| Years2: | 2010 |
| Clubs2: | → 3 de Febrero (loan) |
| Caps2: | 7 |
| Goals2: | 0 |
| Years3: | 2011 |
| Clubs3: | → General Caballero (loan) |
| Caps3: | 29 |
| Goals3: | 16 |
| Years4: | 2013 |
| Clubs4: | → Manta (loan) |
| Caps4: | 17 |
| Goals4: | 3 |
| Years5: | 2014 |
| Clubs5: | → 3 de Febrero (loan) |
| Caps5: | 19 |
| Goals5: | 1 |
| Years6: | 2015–2016 |
| Clubs6: | → Sol de América (loan) |
| Caps6: | 26 |
| Goals6: | 7 |
| Years7: | 2016 |
| Clubs7: | Alianza Atlético |
| Caps7: | 15 |
| Goals7: | 3 |
| Years8: | 2017 |
| Clubs8: | Independiente Asunción |
| Caps8: | 4 |
| Goals8: | 0 |
| Years9: | 2017 |
| Clubs9: | Sportivo Trinidense |
| Caps9: | 9 |
| Goals9: | 1 |
| Years10: | 2018– |
| Clubs10: | Rubio Ñu |
| Caps10: | ? |
| Goals10: | ? |
Hugo Sebastián Santacruz Villalba (born 6 February 1989 in Yasy Cañy, Paraguay) is a Paraguayan footballer currently playing for Club Rubio Ñu.[1]