| Hughes Brook | |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | New York |
| Source1 Location: | Delaware County, New York |
| Mouth: | Little Delaware River |
| Mouth Location: | Delhi, New York, Delaware County, New York, United States |
| Mouth Coordinates: | 42.2583°N -74.8755°W |
| Mouth Elevation: | 1443feet |
Hughes Brook flows into the Little Delaware River east of Delhi, New York, in the eastern part of the country, 400 km northeast of Washington, D.C. Hughes Brook is part of the watershed of the Delaware River at the head of the country.