| Our Lady of Guadalupe Cathedral | |
| Other Name: | Catedral de la Virgen de Guadalupe |
| Location: | Huajuapan de León |
| Country: |  Mexico |
| Denomination: | Roman Catholic Church |
The Our Lady of Guadalupe Cathedral[1] (also Huajuapan de León Cathedral; Spanish; Castilian: Catedral de la Virgen de Guadalupe) is a Catholic church that serves as the headquarters of the Diocese of Huajuapan de Leon[2] in Mexico[3] since 1903. The building is located in the center of the city of Huajuapan de Leon, in the state of Oaxaca.
It is dedicated to the Virgin of Guadalupe. The church was built at the end of the 17th century and various extensions and modifications were made throughout the 19th century. It is decorated almost entirely in Neoclassical style.
The Diocese of Huajuapan de Leon was founded on 25 April 1902 by the papal bull Apostolica Sedes signed by Pope Leo XIII.