HuS-E/2 cells explained

HuS-E/2 cells are immortalized primary human hepatocytes that were isolated from the discarded old liver tissue obtained from a 9-year-old male patient with primary hyperoxaluria (after the approval of ethical committee and required written consent) who had undergone liver transplantation to receive a new liver.[1] Hepatocytes were transduced with hTERT and HPV-E6E7 oncogenes. This immortalized hepatocyte cell line showed similar characteristics to primary hepatocytes, and was beneficial in the study of Hepatitis C and B viruses.[1] [2] [3] [4]

Notes and References

  1. Aly . Hussein H. . Watashi . Koichi . Hijikata . Makoto . Kaneko . Hiroyasu . Takada . Yasutugu . Egawa . Hiroto . Uemoto . Shinji . Shimotohno . Kunitada . Serum-derived hepatitis C virus infectivity in interferon regulatory factor-7-suppressed human primary hepatocytes . Journal of Hepatology . January 2007 . 46 . 1 . 26–36 . 10.1016/j.jhep.2006.08.018 . 17112629 . 2433/135683 . free .
  2. Aly . Hussein Hassan . Qi . Yue . Atsuzawa . Kimie . Usuda . Nobuteru . Takada . Yasutsugu . Mizokami . Masashi . Shimotohno . Kunitada . Hijikata . Makoto . Strain-dependent viral dynamics and virus-cell interactions in a novel in vitro system supporting the life cycle of blood-borne hepatitis C virus . Hepatology . September 2009 . 50 . 3 . 689–696 . 10.1002/hep.23034 . 19489071 . free .
  3. Abe . Yuichi . Aly . Hussein Hassan . Hiraga . Nobuhiko . Imamura . Michio . Wakita . Takaji . Shimotohno . Kunitada . Chayama . Kazuaki . Hijikata . Makoto . Thromboxane A2 Synthase Inhibitors Prevent Production of Infectious Hepatitis C Virus in Mice With Humanized Livers . Gastroenterology . September 2013 . 145 . 3 . 658–667.e11 . 10.1053/j.gastro.2013.05.014 . 23684750 . 2433/178751 . free .
  4. Huang . Hsiu-Chen . Tao . Mi-Hua . Hung . Tzu-Min . Chen . Jui-Chieh . Lin . Zi-Jun . Huang . Cheng . (−)-Epigallocatechin-3-gallate inhibits entry of hepatitis B virus into hepatocytes . Antiviral Research . November 2014 . 111 . 100–111 . 10.1016/j.antiviral.2014.09.009 . 25260897 .

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