HtrA2 peptidase explained

HtrA2 peptidase
Ec Number:3.4.21.108

HtrA2 peptidase (high temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, serine proteinase OMI, OMI/HtrA2 protease, HtrA2/Omi, Omi/HtrA2) is an enzyme.[1] [2] [3] [4] [5] This enzyme catalyses the following chemical reaction

Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met.

This enzyme is upregulated in mammalian cells in response to stress induced by heat shock and tunicamycin treatment.

Notes and References

  1. Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, Alnemri ES . Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2 . The Journal of Biological Chemistry . 278 . 34 . 31469–72 . August 2003 . 12835328 . 10.1074/jbc.C300240200 . free .
  2. Savopoulos JW, Carter PS, Turconi S, Pettman GR, Karran EH, Gray CW, Ward RV, Jenkins O, Creasy CL . Expression, purification, and functional analysis of the human serine protease HtrA2 . Protein Expression and Purification . 19 . 2 . 227–34 . July 2000 . 10873535 . 10.1006/prep.2000.1240 .
  3. Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J . Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi . The Journal of Biological Chemistry . 278 . 49 . 49417–27 . December 2003 . 14512424 . 10.1074/jbc.M308659200 . free .
  4. Gray CW, Ward RV, Karran E, Turconi S, Rowles A, Viglienghi D, Southan C, Barton A, Fantom KG, West A, Savopoulos J, Hassan NJ, Clinkenbeard H, Hanning C, Amegadzie B, Davis JB, Dingwall C, Livi GP, Creasy CL . Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response . European Journal of Biochemistry . 267 . 18 . 5699–710 . September 2000 . 10971580 . 10.1046/j.1432-1327.2000.01589.x . free .
  5. Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y . Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi . Nature Structural Biology . 9 . 6 . 436–41 . June 2002 . 11967569 . 10.1038/nsb795 .

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